Praziquantel is a drug of choice for the treatment of schistosomiasis caused by human species of the genus Schistosoma. The effect of the drug on avian schistosomes is not completely known. Monensin is a drug used for the treatment of coccidiosis, and its effect on avian schistosomes is unknown. In the thesis, we studied the effect of these drugs on avian schistosome Trichobilharzia regenti. Under in vitro conditions, both drugs were effective after 6 hours of incubation. Praziquantel causes an extensive vacuolization of the whole body, while monensis treatment causes vacuolization of the anterior part of body. Higher concentration of praziquantel causes depolymerization of myofilaments and separation of surface membranes. Monensin did not impair muscles, but caused separation of tegumental layer from the basal membrane. Schistosomula in ducks were not killed by the drugs under in vivo conditions, but the worms were damaged by the drugs. Praziquantel caused vacuolization of the tegument and separation of membranes from the surface. Only vacuolization of the tegument occurred in schistosomula from ducks treated with monensin . No damage to the muscles was observed in the case of both drugs. Histological evaluation of the nerve tissue showed that thero no difference between treated and control duck....
| Identifer | oai:union.ndltd.org:nusl.cz/oai:invenio.nusl.cz:306679 |
| Date | January 2012 |
| Creators | Lípová, Pavlína |
| Contributors | Horák, Petr, Chanová, Marta |
| Source Sets | Czech ETDs |
| Language | Czech |
| Detected Language | English |
| Type | info:eu-repo/semantics/masterThesis |
| Rights | info:eu-repo/semantics/restrictedAccess |
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