I choose the topic of phototherapy because of my longlasting interest in this field. Phototherapy is defined as the therapeutic use of light, primarily ultraviolet light. The mode of action on the skin is described as photobiological one and it has been continuously investigated. At its most basic level phototherapy represents the application of energy to skin, which means the delivery of photons to chromophores, the absorbtion of photons in chromophores and the biologic reaction of photon's absorbed energy. This causes the formation of heat and various biochemical effects in the skin. Previously the main role of UV light in phototherapy was thought to be the antimitotic and antiproliferative. Nowadays it is clear that beside them the mode of action is rather immunomodulatory and immunosuppressive. Further possible mechanism of the UV light are detected with increasing investigation of the immune system of skin. The rules and usages of phototherapy in practice at individual dermatological departments and offices differ and there is a need to improve and/or coordinate the protocols in order to reach the optimal risk/benfit ratio. That was one of the reasons for conducting the epidemiological study Phototherapy in Czech Republic. The results shows phototherapy to be an available and relative...
| Identifer | oai:union.ndltd.org:nusl.cz/oai:invenio.nusl.cz:312169 |
| Date | January 2012 |
| Creators | Benáková, Nina |
| Contributors | Cetkovská, Petra, Ditrichová, Dagmar, Pavel, Stanislav, Vašků, Vladimír |
| Source Sets | Czech ETDs |
| Language | Czech |
| Detected Language | English |
| Type | info:eu-repo/semantics/doctoralThesis |
| Rights | info:eu-repo/semantics/restrictedAccess |
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