Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Technology Student: Nikola Mrázková Supervisor of Diploma thesis: Doc. RNDr. Milan Dittrich CSc. Title of Diploma thesis: Formulation of nanoparticles with terbinafine In the theoretical part of this diploma thesis is presented review concerning basic applications of nanotechnology in health service, characteristic of nanoparticles, their dividing and use in pharmacotherapy, especially in targeted drug transport. The focus of the thesis presented here is in experimental part. Particles of submicrom size were fabricated by the using of emusion solvent distribution method in the emulsion of o/w type. Star-like terpolymer of DL- lactic acid and glycolic acid branched on tripentaerytritole as core was used as potential drug carrier. The aim was to prepare the smallest particles as possible. The size and the size distribution were measured by the PCS method by the using of the device Zeta Sizer ZS. The impact of two from the chemical point of view different emulsifiers and two emulsion concentrations on the granulometric parameters of the prepared particles was evaluated. The stability of parameters during storage at lowered temperature and in the frozen state during the one day period after preparation was...
| Identifer | oai:union.ndltd.org:nusl.cz/oai:invenio.nusl.cz:324176 |
| Date | January 2013 |
| Creators | Mrázková, Nikola |
| Contributors | Dittrich, Milan, Šnejdrová, Eva |
| Source Sets | Czech ETDs |
| Language | Czech |
| Detected Language | English |
| Type | info:eu-repo/semantics/masterThesis |
| Rights | info:eu-repo/semantics/restrictedAccess |
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