Charles University in Prague Faculty of Pharmacy in Hradci Králové Department of Pharmaceutical Botany and Ecology Candidate: Kamila Ambrožová Supervisor: PharmDr. Jana Karlíčková, Ph.D. Title of Thesis: Copper reducing activity of isoflavonoids Copper in our body appears only in trace amounts. Despite this fact is an important component of many enzymes, which are responsible for right function of the whole organism. The most important are antioxidant activity, collagen and conective tissue synthesis, formation of pigmentation and cell respiration. Main target of the organism is control the homeostasis of copper, because excess and deficiency of the element could be pathological. Increase level of copper can cause many of civilization diseases. Isoflavones are the plant metabolites of polyfenolic structure which can positively affect different processes in our body. Research is dedicated to anti-inflammatory and estrogenic effects, antioxidant and anticancer aktivity. The elimination and inactivation of radical elements is performed becase of ability of isoflavones to reduce transition elements or chelate them. The aim of this thesis was to determine the reducing activity of seven isoflavonoids - daidzein, genistein, biochanin A, genistin, glycitein, formononetin and prunetin. The highest reduction...
| Identifer | oai:union.ndltd.org:nusl.cz/oai:invenio.nusl.cz:331176 |
| Date | January 2015 |
| Creators | Ambrožová, Kamila |
| Contributors | Karlíčková, Jana, Martin, Jan |
| Source Sets | Czech ETDs |
| Language | Czech |
| Detected Language | English |
| Type | info:eu-repo/semantics/masterThesis |
| Rights | info:eu-repo/semantics/restrictedAccess |
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