The term leishmaniasis can be used to define a group of diseases caused by the Leishmania genus. Human infection may be entirely unapparent or sub-clinical or it may display a spectrum of manifestations ranging from cutaneous involvement throug to the late destruction of the mucous membranes and on to a generalised systemic visceral disease with a fatal outcome. Phosphatidylcholine is the most abundant phospholipid in this parasite{\crq}s membranes. The metabolic pathways leading to biosynthesis are likely to play a critical role in the parasite{\crq}s development and survival and may offer a good target for antileishmanial chemotherapy. Phosphatidylcholine synthesis requires the transportation of a choline precursor from the host. This choline transportation into Leishmania is highly specific for choline and is inhibited by phosphocholine analogues and choline analogues. The aim of this study was to test the effects of the analogues of o-phoshonatomethylcholine and the analogues of phosphocholine for antileishmanial activity.
| Identifer | oai:union.ndltd.org:nusl.cz/oai:invenio.nusl.cz:51862 |
| Date | January 2010 |
| Creators | MATOUŠOVÁ, Linda |
| Source Sets | Czech ETDs |
| Language | Czech |
| Detected Language | English |
| Type | info:eu-repo/semantics/masterThesis |
| Rights | info:eu-repo/semantics/restrictedAccess |
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