<p>The superior sensitivity and selectivity obtained with mass spectrometry
(MS) is hardly matched by other analytical technologies, therefore it is an indispensable
tool for modern society. Traditionally, MS is coupled with chromatography separation
and performed in centralized analytical laboratories, which often requires
extensive sample preparation and expensive instrumentation. With the advancements
in the field of ambient MS and miniature MS, MS analysis at point-of-care (POC)
has become a reality. Ambient MS includes a
variety of methods for sampling and ionization, but they all share a common
feature: they require little to no sample preparation. This has made rapid
analysis of untreated sample possible and speed of MS analysis is significantly
improved. Miniature MS, on the other hand, shrinks down the sizes of
conventional benchtop instruments so they become portable or fieldable. In this
dissertation, I documented the developments of ambient MS methods and applications
of miniature MS for a variety of health-related topics, which include preclinical
pharmacokinetics, intraoperative diagnosis, drug adherence monitoring and food
safety. </p>
| Identifer | oai:union.ndltd.org:purdue.edu/oai:figshare.com:article/10316009 |
| Date | 20 November 2019 |
| Creators | Fan Pu (7874093) |
| Source Sets | Purdue University |
| Detected Language | English |
| Type | Text, Thesis |
| Rights | CC BY 4.0 |
| Relation | https://figshare.com/articles/MASS_SPECTROMETRY_AT_POINT-OF-CARE_SIMPLE_YET_POWERFUL_SOLUTIONS_FOR_BETTER_HEALTH/10316009 |
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