<p>Glaucoma is the leading cause
of irreversible blindness worldwide effecting more than 2.7 million people in
the U.S alone. Treatments exist in the form of both pharmaceutical and surgical
options, but often do not provide the desired efficacy. For example, the
failure rate of a trabeculectomy procedure is 39% within 5 years. Additionally,
none of the current glaucoma treatments allow for closed loop monitoring of
pressure, therefore requiring more frequent doctor visits. Glaucoma management can
be improved through the use of a closed loop application of electroceutical
treatment. The goal is to develop an implantable device that will be inserted
into the eye to monitor intraocular pressure (IOP) and provide responsive therapeutic
stimulation to the eye. I designed a discrete pressure monitoring system that
interacts with a bare die piezoresistive pressure sensor. The system is based
on a Wheatstone bridge design which translates the input resistances of the
pressure sensor into a voltage output. This system has an average accuracy of
0.53 mmHg and draws 295 µW
of power. I then combined this pressure system with data processing code and
Howland current pump stimulation circuitry. This simulation system can output
up to 1.05 mA of current for electroceutical intraocular stimulation to lower
IOP. Future work will involve miniaturizing the circuitries in the form of an
ASIC and packaging the entire system into an ocular implant. This implant can
wirelessly monitor IOP and provide therapeutic stimulation to lower IOP. A
reliable, closed loop method of lowering IOP would greatly benefit the ever-growing
population affected by glaucoma.</p>
| Identifer | oai:union.ndltd.org:purdue.edu/oai:figshare.com:article/8016197 |
| Date | 11 June 2019 |
| Creators | Rachael Swenson (6615704) |
| Source Sets | Purdue University |
| Detected Language | English |
| Type | Text, Thesis |
| Rights | CC BY 4.0 |
| Relation | https://figshare.com/articles/Design_of_a_Closed_Loop_System_for_Glaucoma_Treatment_including_Measurement_of_Intraocular_Pressure_and_Therapeutic_Stimulation_of_the_Eye/8016197 |
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