<p>Motivation
deficits remain an unmet treatment need in schizophrenia. Recent preclinical research
has identified novel mechanisms underlying motivation deficits, namely impaired
effort-cost computations and reduced future reward-value representation
maintenance, that may serve as more effective treatment targets to improve
motivation. The main aim of this study was to test the
feasibility and preliminary effectiveness of a translational mechanism-based
intervention, MEMS (Mobile Enhancement of Motivation in Schizophrenia),
which leverages mobile technology to target these mechanisms with
text-messages. Fifty-six participants with a
schizophrenia-spectrum disorder were randomized to MEMS (<i>n</i> = 27) or a control condition (<i>n</i>
= 29). All participants set recovery goals to complete over eight-weeks. The
MEMS group also received personalized, interactive text-messages each weekday
to support motivation. Retention and engagement
in MEMS was high: 92.6% completed 8 weeks of MEMS, with an 86.1% text-message
response rate, and 100% reported that they were satisfied with the
text-messages. Compared to the control condition, the MEMS group had
significantly greater improvements in interviewer-rated motivation and
anticipatory pleasure and obtained significantly more recovery-oriented goals
at the end of the 8-week period. There were no significant group differences in
performance-based effort-cost computations and future reward-value
representations, self-reported motivation, quality of life, functioning, or
additional secondary outcomes of positive symptoms, mood symptoms, or
neurocognition. Results suggest that MEMS is feasible as a relatively brief,
low-intensity mobile intervention that could effectively improve interviewer-rated
motivation, anticipatory pleasure, and recovery goal attainment in those with
schizophrenia-spectrum disorders. </p>
| Identifer | oai:union.ndltd.org:purdue.edu/oai:figshare.com:article/8101658 |
| Date | 16 October 2019 |
| Creators | Lauren Luther (6685082) |
| Source Sets | Purdue University |
| Detected Language | English |
| Type | Text, Thesis |
| Rights | CC BY 4.0 |
| Relation | https://figshare.com/articles/Mobile_Enhancement_of_Motivation_in_Schizophrenia_A_Pilot_Trial_of_a_Personalized_Text-Message_Intervention_for_Motivation_Deficits/8101658 |
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