Multiple interacting mechanisms control the formation and dissolution of clots to
maintain blood in a state of delicate balance. In addition to a myriad of biochemical
reactions, rheological factors also play a crucial role in modulating the response of
blood to external stimuli. The broad stimuli for clot formation were laid out, more
than a century ago, in, what is now referred to as, VirchowâÂÂs triad. To date, a
comprehensive model for clot formation and dissolution, that takes into account the
biochemical, medical and rheological factors, has not been put into place, the existing
models emphasizing either one or the other of the factors. In this dissertation, a model
is developed for clot formation and dissolution that incorporates many of the relevant
crucial factors that have a bearing on the problem. The model, though just a first step
towards understanding a complex phenomenon goes further than previous models in
integrating the biochemical, medical and rheological factors that come into play. The
model is tested in some simple flow situations as part of an attempt to elucidate
VirchowâÂÂs triad. Extensions to the model, along with detailed numerical studies, will
hopefully aid in a clearer understanding of the phenomenon, and in making relevant
clinical correlations.
| Identifer | oai:union.ndltd.org:tamu.edu/oai:repository.tamu.edu:1969.1/4445 |
| Date | 30 October 2006 |
| Creators | Mohan, Anand |
| Contributors | Rajagopal, Kumbakonam R. |
| Publisher | Texas A&M University |
| Source Sets | Texas A and M University |
| Language | en_US |
| Detected Language | English |
| Type | Book, Thesis, Electronic Dissertation, text |
| Format | 847652 bytes, electronic, application/pdf, born digital |
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