It was nearly a century ago that the viral etiology of sarcomas and leukemia
(leukosis) in the domestic fowl was first described by Ellerman and Bang, working in
Copenhagen, and Rous in New York. Through the following decades, in an attempt to
control these oncogenic diseases which were becoming the main cause of mortality in
commercial poultry, extensive investigation in many veterinary laboratories was
undertaken. Throughout this period and continuing today, advancements in our
understanding of the mechanisms of these viruses are ever expanding. This knowledge has
exponentially expanded since the discovery and in turn the development of molecular,
nucleic acid-based tools to analyze and interpret these viral genomes. This burgeoning
field of research has shed light on countless topics including the elucidation of specific
viral mechanisms of neoplastic induction. It has allowed for the creation of diagnostics
which are vastly superior in sensitivity and specificity than to their non-molecular-based
counterparts, and in the future will lead to the generation of disease resistance in the host.
These topics, in specific regard to molecular studies of avian leukosis virus, will be further
developed in this thesis.
| Identifer | oai:union.ndltd.org:tamu.edu/oai:repository.tamu.edu:1969.1/4716 |
| Date | 25 April 2007 |
| Creators | Mozisek, Blayne Myron |
| Contributors | El-Attrache, John |
| Publisher | Texas A&M University |
| Source Sets | Texas A and M University |
| Language | en_US |
| Detected Language | English |
| Type | Book, Thesis, Electronic Thesis, text |
| Format | 540176 bytes, electronic, application/pdf, born digital |
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