statistics, 2) unadjusted inferential statistics, 3) stratified analysis, and 4) multivariable
models.
My investigation produced results in accord with generally accepted notions in
addition to significant findings that interestingly counter current preconceptions. Intraspecies
contact was more common than inter-species, with indirect contact occurring
more frequently than direct. Direct contact between species occurred extremely rarely.
The most important factors that influenced the rate of contact for both species were
water, winter, and cultivated fields.
Information regarding probability of infectious agent survival and transfer will be
used in the future to advance current epidemiological models, including geographicautomata
(Ward et al. 2007: In Press) and cellular automata models (Doran and Laffan
2005) to better understand and manage integrated domestic cattle and free-ranging
wildlife populations. Such modeling provides essential and necessary knowledge for
developing prevention, detection, response, and recovery strategies – employed in
advance, during, and after a disease outbreak, respectively. responsible for telomere activation. In addition tac5 showed sensitivity to hydrogen
peroxide treatment, suggesting a novel role of telomerase in the mitochondrial
environment.
Chapter III reports the role of PARP proteins in plant telomere biology. Both
AtPARP1 and AtPARP2 are transcriptionally upregulated in response to DNA damage
treatment or telomere dysfunction. However, in contrast to mammalian PARPs, the
Arabidopsis proteins do not appear to have a function in telomere length maintenance as
indicated by TRF analysis or in promoting genome stability maintenance as indicated by
cytogenetic studies. Further analysis of PARP interactions at dysfunctional telomeres in
the genetically tractable Arabidopsis model may provide insight into the cellular response
to dysfunctional telomeres.
As explained in chapter IV, the yeast two-hybrid screen was utilized to confirm the
interactions of ATR with AtPOT2 and Ku80 and to identify novel interacting partners of
Arabidopsis telomere proteins. At2g04410 (Unknown protein) was identified as a direct
interacting partner of AtPOT1. This interaction was confirmed in vitro by coimmunoprecipitation
assay. Further analysis of the unknown protein may shed light on
AtPOT1’s function in telomere maintenance.
| Identifer | oai:union.ndltd.org:tamu.edu/oai:repository.tamu.edu:1969.1/ETD-TAMU-1238 |
| Date | 15 May 2009 |
| Creators | Jasti, Madhuri |
| Contributors | Dorothy E. Shippen |
| Source Sets | Texas A and M University |
| Language | en_US |
| Detected Language | English |
| Type | Book, Thesis, Electronic Thesis, text |
| Format | electronic, application/pdf, born digital |
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