Abstract
Restless legs syndrome (RLS) is a sensori-motor neurological disorder characterzed by paraesthesia, dysaesthesia and irresistibile urge to move the legs especially at night. Its prevalence is much higher among dialysis patients at 12 to 62% compared to 3 to 9% in the general population. In our study we investigated the association between RLS and cardiovascular events risk and laboratory parameters in End-stage kidney disease (ESKD) patients on dialysis.
We studied 100 ESKD patients undergoing hemodialysis that were enrolled in an 18-months prospective observational study.
The main outcomes were the association of RLS with new cardiovascular events and cardiovascular mortality.
RLS affected 31% of the study population. It was associated with female gender, gradual reduction in residual dieresis, lower albumin (P=0.039) and inflammation, but not the dialysis parameters spKt/V and URR.
During observation, 47% of patients experienced new cardiovascular events (64.5% with and 39.1% without RLS; P=0.019).
Mortality was 20.0% in all patients, 32.3% in those with and 14.5% in patients without RLS (P=0.04).
This study confirmed the high prevalence of RLS among dialysis patients and the associations between the severity of RLS and the risk of new cardiovascular events and higher short-term mortality.
Abstract
Restless legs syndrome (RLS) is a sensori-motor neurological disorder characterzed by paraesthesia, dysaesthesia and irresistibile urge to move the legs especially at night. Its prevalence is much higher among dialysis patients at 12 to 62% compared to 3 to 9% in the general population. In our study we investigated the association between RLS and cardiovascular events risk and laboratory parameters in End-stage kidney disease (ESKD) patients on dialysis.
We studied 100 ESKD patients undergoing hemodialysis that were enrolled in an 18-months prospective observational study.
The main outcomes were the association of RLS with new cardiovascular events and cardiovascular mortality.
RLS affected 31% of the study population. It was associated with female gender, gradual reduction in residual dieresis, lower albumin (P=0.039) and inflammation, but not the dialysis parameters spKt/V and URR.
During observation, 47% of patients experienced new cardiovascular events (64.5% with and 39.1% without RLS; P=0.019).
Mortality was 20.0% in all patients, 32.3% in those with and 14.5% in patients without RLS (P=0.04).
This study confirmed the high prevalence of RLS among dialysis patients and the associations between the severity of RLS and the risk of new cardiovascular events and higher short-term mortality.
| Identifer | oai:union.ndltd.org:unibo.it/oai:amsdottorato.cib.unibo.it:3648 |
| Date | 20 May 2011 |
| Creators | Persici, Elisa <1975> |
| Contributors | La Manna, Gaetano |
| Publisher | Alma Mater Studiorum - Università di Bologna |
| Source Sets | Università di Bologna |
| Language | Italian |
| Detected Language | English |
| Type | Doctoral Thesis, PeerReviewed |
| Format | application/pdf |
| Rights | info:eu-repo/semantics/openAccess |
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