OBJECTIVE: To assess the effectiveness of ultrasound in the antenatal prediction of symptomatic
congenital cytomegalovirus infection.
STUDY DESIGN: The sonograms of 650 fetuses from mothers with primary cytomegalovirus
infection were correlated to fetal/neonatal outcome. Infection status was disclosed by viral urine
isolation at birth or CMV tissue inclusions at autopsy. Classification of symptomatic disease was
based on postnatal clinical/laboratory findings or macroscopic evidence of tissue damage at
autopsy.
RESULTS: Ultrasound abnormalities were found in 51/600 (8.5%) mothers with primary infection
and in 23/154 congenitally infected fetuses (14.9%). Symptomatic congenital infection resulted in
18/23 and 68/131 cases with or without abnormal sonographic findings, respectively. Positive
predictive values of ultrasound versus symptomatic congenital infection was 35.3% relating to all
fetuses/infants from mothers with primary infection and 78.3% relating to fetuses/infants with
congenital infection.
CONCLUSION: When fetal infection status is unknown, ultrasound abnormalities only predict
symptomatic congenital infection in a third of cases.
| Identifer | oai:union.ndltd.org:unibo.it/oai:amsdottorato.cib.unibo.it:970 |
| Date | 09 June 2008 |
| Creators | Simonazzi, Giuliana <1973> |
| Contributors | Rizzo, Nicola |
| Publisher | Alma Mater Studiorum - Università di Bologna |
| Source Sets | Università di Bologna |
| Language | Italian |
| Detected Language | English |
| Type | Doctoral Thesis, PeerReviewed |
| Format | application/pdf |
| Rights | info:eu-repo/semantics/openAccess |
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