<p>Within this doctoral thesis, eighteen new compounds, polycyclic polyprenylated<br />acylphloroglucinols, were isolated from petrol ether extract of <em>Hypericum barbatum</em><br />plant. The compounds are named hyperibarbins A–R. For hyperibarbins A–D,<br />cytotoxicity towards carcinogenic cells and antibacterial activity were evaluated. All<br />four compounds exhibited intermediate activity towards tumor cells in vitro. Although<br />inactive towards Gram negative bacteria, examined compounds have expressed<br />extraordinary bacteriostatic activity towards Gram positive bacterial strains.<br />Hyperibarbins C, E, N and K were, since having endoperoxide bridge in their structures,<br />tested for antiprotozoal activity, but shown intermediate activity towards the examined<br />parasite strains. All goals set for this doctoral thesis at the beginning have been fully<br />met, with isolation of new compounds, described andcompletely chemically<br />characterized for the first time.</p> / <p>U okviru ove doktorske disertacije izolovano je osamnaest novih jedinjenja, policikličnih poliprenilovanih acilfloroglucinola, iz petroletarskog ekstrakta biljke <em>Hypericum barbatum</em>. Imena jedinjenja su hiperibarbini A–R. Za hiperibarbine A–D, ispitana je citotoksičnost prema kancerogenim ćelijama i antibakterijska aktivnost. Sva četiri jedinjenja su ispoljila srednju aktivnost prema tumorskim ćelijama <em>in vitro</em>. Iako neaktivni prema Gram negativnim bakterijama, ispitana jedinjenja su ispoljila izuzetnu bakteriostatsku aktivnost prema sojevima Gram pozitivnih bakterija. Hiperibarbini C, E, N i K su, zbog posedovanja endoperoksidnog prstena u svojoj strukturi, testirana na antiprotozoalnu aktivnost, ali su pokazali srednju aktivnost prema ispitanim sojevima parazita. Svi ciljevi postavljeni na početku izrade ove doktorske disertacije su do kraja ispunjeni, sa izolacijom novih, prvi put opisanih i u potpunosti hemijski okarakterisanih jedinjenja.</p>
| Identifer | oai:union.ndltd.org:uns.ac.rs/oai:CRISUNS:(BISIS)105517 |
| Date | 19 February 2018 |
| Creators | Šibul Filip |
| Contributors | Orčić Dejan, Mimica-Dukic Neda, Popsavin Mirjana, Svirčev (Jovin) Emilija, Četojević-Simin Dragana |
| Publisher | Univerzitet u Novom Sadu, Prirodno-matematički fakultet u Novom Sadu, University of Novi Sad, Faculty of Sciences at Novi Sad |
| Source Sets | University of Novi Sad |
| Language | English |
| Detected Language | English |
| Type | PhD thesis |
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