In two separate experiments, weight adjusted doses of nocodazole and acrylamide were injected intraperitoneally at various time intervals into twelve week old female mice. Within the nocodazole experiment, the doses were injected at varying time intervals before and after mating. On day seventeen of gestation, the female mice were sacrificed and their uterine contents examined. Nocodazole induced a significant increase in reproductive pathology per total implants when administered one hour after mating to the (SECxC57BL)F, stock: 5.00% total deads, 70.23% moles, and 3.41% abnormal fetuses. Acrylamide treatment produced a significant reduction in live births when administered six hours after mating: 50.86% moles and 46.46% living fetuses per total implants.
| Identifer | oai:union.ndltd.org:unt.edu/info:ark/67531/metadc500254 |
| Date | 05 1900 |
| Creators | Oliva, Jean L. (Jean Louise) |
| Contributors | White, Olivia Masih, Lacko, Andras G., O'Donovan, Gerard A. |
| Publisher | University of North Texas |
| Source Sets | University of North Texas |
| Language | English |
| Detected Language | English |
| Type | Thesis or Dissertation |
| Format | iv, 58 leaves, Text |
| Rights | Public, Oliva, Jean L. (Jean Louise), Copyright, Copyright is held by the author, unless otherwise noted. All rights reserved. |
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