名古屋大学博士学位論文 学位の種類:博士(工学) 学位授与年月日:2014-03-25

名古屋大学博士学位論文 学位の種類:博士(工学) 学位授与年月日:2014-03-25

名古屋大学博士学位論文 学位の種類:博士(工学) 学位授与年月日:2014-03-25

Submitted in partial compliance with the requirements of the Master’s Degree in Technology: Homoeopathy, Durban University of Technology, 2013. / Introduction Acne vulgaris is a common skin condition (disorder of the pilosebaceous duct) which is universal in adolescence. Acne vulgaris can persist into adulthood, with 1% of males and 5% of females requiring treatment until 40 years of age. Aim The aim of this study was to determine the efficacy of a homoeopathic complex (Kalium bromatum 9CH, Natrum muriaticum 9CH, Selenium 9CH, Sulphur 9CH and Thuja occidentalis 9CH), compared to placebo, in the treatment of acne vulgaris. Methodology A total of 37 participants between the ages of 18 and 31 were recruited from the Greater Durban area by means of poster advertisements placed on notice boards in shops, pharmacies, health shops, hospitals, schools, tertiary institutions including Durban University of Technology, and other public areas. Handouts were also left at these areas for people to take home. The final sample consisted of 34 participants due to the drop out of 3 participants. After participants read an information letter (English or Zulu), fulfilled the inclusion and exclusion criteria of the research, were diagnosed as having acne vulgaris by the researcher and completed an informed consent form (English or Zulu) and confidential patient information form (English or Zulu), they were randomly assigned to an experimental (homoeopathic complex) group and a control (placebo) group. In the final sample, the experimental (homoeopathic complex) group consisted of 7 males and 10 females, and the control (placebo) group consisted of 9 males and 8 females. Consultations took place at the Durban University of Technology Homoeopathic Day Clinic, and consisted of 3 consultations, an initial consultation followed by 2 follow-up consultations at 3 weekly intervals. The treatment period for each participant was therefore 6 weeks. A case history was taken and a complete physical examination was performed for all participants. The Leeds counting technique was used to assess and measure the response to treatment. The lesions assessed were the non-inflamed lesions (blackheads and whiteheads), inflamed lesions (papules, pustules, nodules, cysts and deep pustules) and the total number of acne lesions (number of non-inflamed and inflamed lesions combined). The response to treatment was measured in terms of a reduction in the number of non-inflamed, number of inflamed and total number of acne lesions, on the face, over the 6 weeks. SPSS version 20 was used to analyse the data. A p value of < 0.05 was considered as statistically significant. Non-parametric tests were used to analyse the data. The number of non-inflamed, number of inflamed and total number of acne lesions were compared within groups using the Friedman test and between groups using the Mann-Whitney U test. The number of lesions was compared separately for males and females, and also without gender classification. Results In females, the control (placebo) group showed a statistically significant reduction in the total number of acne lesions when compared to the experimental group (p = 0.034). However, as a whole, it was concluded from the results of this study that there was no significant difference in the number of non-inflamed (p = 0.193), number of inflamed (p = 0.290), and total number of acne lesions (p = 0.193) between the experimental (homoeopathic complex) and control (placebo) groups. Both groups showed a similar reduction when compared to each other. Conclusion It was concluded that the homoeopathic complex was not effective in the treatment of acne vulgaris.

Submitted in partial compliance with the requirements for the Master’s Degree in Technology: Homoeopathy, Durban University of Technology, 2013. / The proving study of Strychnos henningsii 30CH was primarily conducted to extract as many symptoms as possible from healthy provers to create a Homoeopathic picture of the drug. This would allow practitioners in clinical practise to prescribe Strychnos henningsii 30CH based on the Law of Similars. The second part of this study was to assess the symptoms produced, and thereafter determine the relationship to the natural history of the Strychnos henningsii plant as it relates to the Doctrine of Signatures. Methodology The Homoeopathic drug proving of Strychnos henningsii 30CH took the form of a mixed-method triple-blind, placebo-controlled study. The proving population consisted of a minimum of 32 subjects who met all the inclusion criteria. The proving was conducted by 4 M.Tech.Hom students, under the supervision of the principal researcher. The 32 provers were randomly divided into four equal groups of eight provers, with each group supervised by one of four M.Tech.Hom student researchers. Nine powders each of the respective test substance (verum or placebo) was randomly assigned by an independent clinician to 32 prover numbers (16 verum and 16 placebo). Randomisation was conducted by an independent clinician who was unaware of the proving substance. The physical and behavioural symptoms that were noted by the provers were extracted from their prover journals, case-histories and post-proving group discussions. This was then written up into Materia Medica and Repertory format and graded accordingly. Once this proving data was captured it allowed for the application of the Doctrine of Signatures. During this analysis, similarities were compared between the behaviour of the patient and the behaviour of the substance in nature, which indicated the therapeutic action of the plant. The main characteristics used to link the Strychnos henningsii plant in its natural state to the Homoeopathic remedy developed was the plants habitat, kingdom, toxicity, structure, Anthroposophy and Vibrational therapy. By applying the Anthroposophical and vibrational therapy view, it allowed the researcher to establish a more holistic approach. Results A broad spectrum of symptoms was obtained which resulted in the formation of 876 rubrics. The areas that Strychnos henningsii had a profound affinity for were the mind which yielded 170 rubrics, head (76 rubrics), extremities (82 rubrics), dreams (91 rubrics) and the generals (80 rubrics). These rubrics were used in the evaluation of the Doctrine of Signatures. The sensation of heat, dryness and burning appeared to be an integral part of the manifestation of symptoms in this proving study which correlated to the habitat of the plant in its natural environment. Many mind themes were noted, but in particular emotional sensitivity was one of the major themes. Sensitivity is the Plant Kingdom’s key sensation in general. The remedy was prepared using the bark of the plant which contained high levels of the alkaloid strychnine. This reflected in the provers symptoms (itching, skin eruptions, cramps, stiffness, tingling). The structure, colour, mode and speed of growth were all factors which yielded satisfactory comparative results. Chakras, Colour Therapy and Anthroposophy allowed the researcher to apply a more dynamic scientific methodology. This tied in well with the Doctrine of Signatures and essentially provided a broader understanding of the remedy. Conclusion The hypotheses of this study were largely validated by the symptoms produced and analysis conducted, after applying the scientific methodology. The Doctrine of Signatures evaluation helped to reveal the intrinsic nature of Strychnos henningsii, further highlighting the underlying themes in the remedy and explained certain symptoms in more detail and finally distinguished between the behaviour of the patient and the substance in nature aiding us with a better understanding for clinical practise. It is important to note that recommendations have been made for future provings.

Patch grazing may be an important factor providing the focus from which wide-scale veld degradation has occurred in the humid grasslands of KwaZulu-Natal. A number of discrete studies were therefore initiated to examine the patch grazing patterns and selected factors which may influence patch grazing at two sites in the humid grasslands of KwaZulu-Natal. The sites were located at Ukulinga Research Farm, situated in the Southern Tall Grassveld, and Kokstad Research Station in the Highland Sourveld. An investigation into the frequency and intensity of gazing patches and non-patches at Ukulinga Research Farm indicated that patch grazing was most evident and most extensive during summer and autumn. As forage in the patches became limiting during winter animals were forced to forage in areas not frequently grazed during the season. The patch grazing pattern was further modified by the time of grazing commencement after a burn in early spring. Early grazing significantly reduced the extent of patch grazing. With early stocking animals were forced to graze less selectively while with increased delay in the commencement of grazing, animals became increasingly patch-selective. Early grazing in conjunction with an autumn rest and heavy grazing during winter could significantly reduce patch grazing. Urine and dung significantly influenced the patch grazing pattern. The sward surrounding a urine deposit was preferentially grazed by both cattle and sheep for a period of at least six months after deposition. Cattle rejected the sward surrounding cattle and sheep dung immediately after deposition and for a period of up to six months. Sheep also rejected cattle and sheep dung patches immediately after deposition. As dung deposits aged, sheep tended to increase their grazing around both cattle and sheep dung pats, and after six months dung did not seem to influence sheep grazing. Urine may be an important factor influencing patch initiation and consequent patch development. A study to examine the characteristics of patches and non-patches in the Highland Sourveld revealed that patches were characterised by lower soil moisture, soil depth and hydraulic conductivity, but by a higher soil nutrient status. Patches and non-patches could also be distinguished in terms of species composition and basal cover. Patches were characterised by Increaser II species, especially Microchloa caffra and, non-patches by Increaser I species such as Trachypogon spicatus, Alioteropsis semialata and Eulalia villosa. Three seasons of patch grazing at Kokstad Research Station negatively influenced the vigour of Themeda triandra in patches relative to the non-patches. The vigour of T. triandra in patches was consistently low throughout a full season's rest. The vigour of T. triandra in non-patches was initially significantly higher than the vigour in the patches and remained so for c. 24 weeks. Vigour measurements at the start of the following season showed that photosynthate accumulation had taken place and a full seasons rest proved to be sufficient in restoring the vigour of T. triandra in patches to the same level as that in non-patches. A full seasons rest did, however, not prevent animals from regrazing the same previously grazed patches the following season. Growth in patches also started c. six weeks later than in nonpatches and above-ground herbage production in patches was significantly lower than nonpatches for at least 20 weeks after a bum. At the end of a full season's rest above-ground herbage production in patches was still slightly lower than that in non-patches possibly due to a difference in species composition between patches and non-patches. Some implications of patch grazing are discussed together with an evaluation of some management recommendations for the humid grasslands with the aim of reducing the potential for patch degradation. / Thesis (M.Sc.)-University of Natal, Pietermaritzburg, 1995.

Cloud computing has brought great benefits in cost and flexibility for provisioning services. The greatest challenge of cloud computing remains however the question of security. The current standard tools in access control mechanisms and cryptography can only partly solve the security challenges of cloud infrastructures. In the recent years of research in security and cryptography, novel mechanisms, protocols and algorithms have emerged that offer new ways to create secure services atop cloud infrastructures. This report provides introductions to a selection of security mechanisms that were part of the "Cloud Security Mechanisms" seminar in summer term 2013 at HPI. / Cloud Computing hat deutliche Kostenersparnisse und verbesserte Flexibilität bei der Bereitstellung von Computer-Diensten ermöglicht. Allerdings bleiben Sicherheitsbedenken die größte Herausforderung bei der Nutzung von Cloud-Diensten. Die etablierten Mechanismen für Zugriffskontrolle und Verschlüsselungstechnik können die Herausforderungen und Probleme der Sicherheit von Cloud-Infrastrukturen nur teilweise lösen. In den letzten Jahren hat die Forschung jedoch neue Mechanismen, Protokolle und Algorithmen hervorgebracht, welche neue Möglichkeiten eröffnen die Sicherheit von Cloud-Anwendungen zu erhöhen. Dieser technische Bericht bietet Einführungen zu einigen dieser Mechanismen, welche im Seminar "Cloud Security Mechanisms" im Sommersemester 2013 am HPI behandelt wurden.

Jacobi equations constitute a set of nonlinear partial differential equations which arise from the implementation in an arbitrary system of coordinates of a Poisson structure defined on a finite-dimensional smooth manifold. Certain skew-symmetric solutions of such equations are investigated in this dissertation. This is done from a twofold perspective including both the determination of new solution families as well as the construction of new global Darboux analyses of Poisson structures. The most general results investigated refer to the case of solutions of arbitrary dimension. The perspective thus obtained is of interest in view of the relatively modest number of solution families of this kind reported in the literature. In addition, the global Darboux analysis of structure matrices deals, in first place, with the global determination of complete sets of functionally independent distinguished invariants, thus providing a global description of the symplectic structure of phase space of any associated Poisson system; and secondly, with the constructive and global determination of the Darboux canonical form. Such kind of analysis is of interest because the construction of the Darboux coordinates is a task only known for a limited sample of Poisson structures and, in addition, the fact of globally performing such reduction improves the scope of Darboux' theorem, which only guarantees in principle the local existence of the Darboux coordinates. In this work, such reductions sometimes make use of time reparametrizations, thus in agreement with the usual definitions of system equivalence. In fact, time reparametrizations play a significant role in the understanding of the conditions under which the Darboux canonical form can be globally implemented, a question also investigated in detail in this dissertation. The implications of such results in connection with integrability issues are also considered in this context. The dissertation is structured as follows. Chapter 1 is devoted to the revision of diverse classical and well-known results that describe the basic framework of the investigation. The original contributions of the thesis are included in Chapters 2 to 4. Finally, the work ends in Chapter 5 with the presentation of some conclusions.

La problemática del cambio techno-tipológico durante el Paleolítico Medio es una cuestión debatida y no resuelta en los estudios de los comportamientos técnicos de los neandertales. El proyecto de esta tesis de doctorado tiene como objetivo contribuir a la discusión en curso añadiendo nuevos datos de dos yacimientos claves Europeos, Abric Romaní (España) (nivel O y M), y la Cueva de Fumane (Italia) (unidad A9 y A5+A6). El trabajo está enfocado en el cambio entre la tecnología Levallois y discoide, que ocurre en las secuencias arqueológicas de los dos yacimientos durante el MIS3. El estudio se ha llevado a cabo desde una perspectiva cuantitativa, teniendo en consideración los conceptos de Human Behavioral Ecology y los aspectos de costes y beneficios relacionados con el cambio de las estrategias de talla. / The problematic of the techno-typological change during the Middle Paleolithic is a debated and unresolved issue in the study of Neanderthals technical behaviors. The project of this Ph.D. thesis aims to contribute to the on-going discussion adding new data from two European key sites, Abric Romaní (Spain) (level O and M), and Fumane Cave (Italy) (unit A9 and unit A5+A6). The work is focused on the particular shift between Levallois and discoid technology that occurred in the archaeological sequences of the two sites during the MIS3. The study will be carried out with a quantitative perspective taking in considerations the concepts of the Human Behavioral Ecology and the aspects of costs and benefits related with the change of the knapping strategies

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