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The Global ETD Search service is a free service for researchers
to find electronic theses and dissertations. This service is
provided by the
Networked Digital Library of Theses and Dissertations.
Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
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Showing 1 to 1 of 1 (0.045 seconds)Spelling suggestions: "subject:"(carene)aruthenium"" "subject:"(carene)diruthenium""
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Synthesis and anticancer activity evaluation of η5-C5(CH3)4R ruthenium complexes bearing chelating diphosphine ligandsRodríguez-Bárzano, A., Lord, Rianne M., Basri, A.M., Phillips, Roger M., Blacker, A.J., McGowan, P.C. 05 January 2015 (has links)
Yes / The complexes [RuCp*(PP)Cl] (Cp* = C5Me5; [1], PP = dppm; [4], PP = Xantphos), [RuCp#(PP)Cl] (Cp# =
C5Me4(CH2)5OH; [2], PP = dppm; [5], PP = Xantphos) and [RuCp*(dppm)(CH3CN)][SbF6] [3] were synthesized
and evaluated in vitro as anticancer agents. Compounds 1–3 gave nanomolar IC50 values against
normoxic A2780 and HT-29 cell lines, and were also tested against hypoxic HT-29 cells, maintaining their
high activity. Complex 3 yielded an IC50 value of 0.55 ± 0.03 μM under a 0.1% O2 concentration.
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