Thesis (B.A. (Hons.)) - University of Queensland, 2005. / Includes bibliography.

Thesis (B.Sc)--University of Hong Kong, 1992. / A dissertation submitted in partial fulfilment of the requirements for the Bachelor of Science (Speech and Hearing Sciences), University of Hong Kong, April 30, 1992. Also available in print.

Thesis (M.S.)--Bowling Green State University, 2006. / Document formatted into pages; contains ix, 154 p. : ill. Includes bibliographical references.

Thesis (M. Communication Pathology)--University of Pretoria, 2005. / Summary in English and Afrikaans. Includes bibliographical references.

Thesis (Ph.D.)--University of Nebraska-Lincoln, 2006. / Title from title screen (site viewed May 23, 2007). PDF text: vi, 79 p. : ill. ; 0.35Mb UMI publication number: AAT 3236907. Includes bibliographical references. Also available in microfilm and microfiche formats.

Thesis (M.S.)--Oregon State University, 2001. / Typescript (photocopy). Includes bibliographical references (leaves 45-47). Also available on the World Wide Web.

Thesis (Ph.D.)--University of Nebraska-Lincoln, 2008. / Title from title screen (site viewed Jan. 13, 2009). PDF text: ix, 92 p. : col. ill. ; 2 Mb. UMI publication number: AAT 3315879. Includes bibliographical references. Also available in microfilm and microfiche formats.

Thesis (Ph. D.)--University of Sydney, 2008. / Title from title screen (viewed Nov. 26, 2008) Includes questionnaires. Submitted in fulfilment of the requirements for the degree of Doctor of Philosophy to the Discipline of Medicine, Faculty of Medicine. Includes bibliography. Also available in print form.

Thesis (Ph.D.)--Boston University / The purpose of this study was to investigate the relationship between the texture of the test stimulus and the rate of the negative after-effect of motion. An interaction theory based on contour phenomena was proposed to account for the effects of texture. The recent clinical literature has consisted mainly of studies which attempt to use the negative after-effect to diagnose brain damage. These studies have produced equivocal results. Systematic examination of the parameters of the after-effect has been limited by a lack of adequate techniques. Leads furnished by te earlier European literature on the effect have been neglected [TRUNCATED]

Unrepaired, or misrepaired, DNA damage can be carcinogenic or mutagenic; thus functional DNA damage repair pathways are essential for the safeguarding of the genome. SNM1B is a 5' to 3' exonuclease implicated in the repair of damaged DNA, particularly the repair of interstrand crosslinks. Genetic studies have identified SNPs in the SNM1B gene as related to cancer risk. One of these (rs11552449) encodes a single amino acid change, H61Y. This study shows that WT and H61Y SNM1B have comparable in vitro biochemical and biophysical characteristics. The structures of both WT and H61Y C-terminally truncated SNM1B (Δ-SNM1B) were solved to 2.8 and 3.1 Å, respectively, and reveal similar structural properties. The structure of WT Δ-SNM1B was also reported (to 1.8 Å) with two 2'-deoxy-5'- adenosine monophosphate molecules in the active site. The structure of SNM1B shows an accessible extended active site, which may facilitate the binding of a variety of non-canonical DNA substrates. Accordingly, in vitro, WT and H61Y SNM1B are able to exonucleolytically process a wide range of structurally diverse DNA substrates. By utilising SNM1B depleted cell lines, this study also shows that SNM1B is required for DNA repair in response to treatment with DNA-crosslinking genotoxic agents (including cisplatin and SJG-136). This study also identifies the novel double strand break repair factor, EXD2, as having intrinsic 3' to 5' exonuclease activity. EXD2 was shown to have enzymatic activity on a variety of substrates in vitro, including replication fork intermediates, 'nicked' or 'gapped' DNA duplexes, and RNA based substrates. Together with the cellular data this suggests a role for EXD2 in nucleolytically processing RNA or DNA-based intermediates in damage repair pathways.