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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
141

Modeling Complex Networks via Graph Neural Networks

Yella, Jaswanth 05 June 2023 (has links)
No description available.
142

Identification and Characterization of Novel Antiretroviral Compounds: from Small Molecule Library Screening to Rationally Designed Compounds

Jegede, Oyebisi 27 July 2007 (has links)
No description available.
143

Spectroscopic methods for drug-discovery targeting RNA thermometers

Sieg, Jacob P. 26 April 2017 (has links)
No description available.
144

Optimization of Synthetic Flavonolignans to Target Embryonic Signaling in Metastatic Ovarian and Colon Cancer.

Amawi, Haneen January 2017 (has links)
No description available.
145

Investigation and Characterisation of Protein-Ligand Interactions: SRA-Ribonucleic Acid Recognition and Anti-Microbial Drug Discovery

Davis, Caroline M. 10 September 2015 (has links)
No description available.
146

SPECTROSCOPIC CHARACTERIZATION OF ZINC HYDROLASES NDM-1 AND MMP-1 FOR DRUG DISCOVERY

yang, hao 27 July 2015 (has links)
No description available.
147

A novel and potent antileishmanial agent: in silico discovery, biological evaluation and analysis of its structure-activity relationships

Delfin, Dawn Athelsia 25 June 2007 (has links)
No description available.
148

Targeting the phosphoinositide-dependent protein kinase-2 for anticancer drug discovery

Lee, Su-Lin 25 June 2012 (has links)
No description available.
149

Synthesis of Substituted Pyrrolidines / Syntes av substituerade pyrrolidiner

Sjölin, Olof January 2016 (has links)
The task of medicinal chemists in a drug discoveryproject is to synthesize/design analogues to the screening hits, simultaneouslyincreasing target potency and optimizing the pharmacological properties.  This requires a wide selection of moleculesto be synthesized, where both synthetic feasibility and price of startingmaterials are of great importance. In this work, a synthetic pathway from cheapand readily available starting materials to highly modifiable 2,4-disubstitutedpyrrolidines is demonstrated. Previously reported procedures to similarpyrrolidines use expensive catalysts, requires harsh conditions and requiresnon-commercially available starting materials. The suggested pathway herein has demonstrated great possibility forvariation in the 4-position, including fluoro, difluoro, nitrile and alcoholfunctional groups. There are several areas in which the synthesis can beimproved and expanded upon. Improvements can be made by optimizing thedescribed reaction conditions and further expansion of possible modificationsin both 2- and 4-position could be explored.
150

A HIGH-THROUGHPUT SCREEN TO IDENTIFY SMALL MOLECULES THAT SELECTIVELY TARGET TUMOR-INITIATING CELLS IN A MOUSE MODEL OF HER2-INDUCED BREAST CANCER

Giacomelli, Andrew O. 10 1900 (has links)
<p><strong>A growing body of evidence suggests that most human tumors, including those of the breast, are organized as cellular hierarchies. Positioned at the apex of these hierarchies are tumor-initiating cells (TICs), which are capable of limitless self-renewal and also differentiate, to give rise to various populations of non-tumorigenic cells that make up the bulk of the tumor. Importantly, recent findings have demonstrated that TICs are refractory to current best practice therapies, and thus likely account for high rates of tumor recurrence following remission. Therefore, it will likely be important to identify novel means of targeting TICs in order to achieve durable cancer cures.</strong></p> <p><strong>Using a highly sensitive transplantation assay, our laboratory previously showed that mammary tumors arising in various strains of transgenic mice comprise a very high fraction of TICs, and that when cells from these tumors are propagated in serum-free medium as tumorspheres, the high frequency of TICs is maintained. We therefore sought to use mouse mammary tumorspheres as an <em>in vitro</em> system with which to identify TIC-targeted agents and carried out a high-throughput screen of nearly 32,000 small molecules. To eliminate compounds showing general toxicity, we employed mouse mammospheres, which primarily comprise normal mammary epithelial stem and progenitor cells, in a secondary screen. Using this platform, we identified a small molecule that selectively targeted tumorsphere-derived cells <em>in vitro</em> and led to tumor growth arrest and tumor cell death <em>in vivo</em>. This study illustrates the utility of mouse models and high throughput screening to identify compounds which may target TICs but spare untransformed stem cells.</strong></p> / Master of Science (MSc)

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