Objective: The absence of Dlx1/Dlx2 results in defects in neural differentiation and migration in the developing forebrain and retina. To further understand genetic regulation of neural differentiation and migration by Dlx genes, we examined transcriptional regulation of p107. Results: DLX2 occupies the p107 promoter in situ in the developing forebrain and retina and binds directly to sequences for the p107 promoter in vitro. In the absence of Dlx1/Dlx2, we observe reduced p107 expression. DLX2 binding to the p107 promoter results in significant activation of luciferase reporter gene expression in vitro. Conclusions: DLX2 binds to the p107 promoter in situ and in vitro, resulting in the activation of p107 expression in both the developing forebrain and retina. These findings contribute to our knowledge of genetic regulation of neurogenesis by Dlx homeobox genes and may contribute to identification of novel targets for disorders of neuronal differentiation and migration.

Thesis (Ph. D.)--University of Texas at Austin, 2007. / Vita. Includes bibliographical references.

Thesis (Ph.D. - Arid Lands Resource Sciences)--University of Arizona. / Includes bibliographical references (leaves 210-226).

Diss. (sammanfattning) Stockholm : Karol. inst. / Härtill 7 uppsatser.

Diss. (sammanfattning) Stockholm : Karol. inst. / Härtill 5 uppsatser.

Thesis (Ph.D.)--Murdoch University, 2003. / Thesis submitted to the Division of Health Sciences. Bibliography: leaves 171-184.

Thesis (Ph. D.)--University of New South Wales, 2004. / Also available online.

Thesis PlanB (M.S.)--University of Wisconsin--Stout, 2008. / Includes bibliographical references.

Thesis (Ph.D.) - University of Glasgow, 1983. / Thesis submitted to the Department of Management Studies, University of Glasgow, 1983. Includes bibliographical references. Print version also available.

Thesis (M.S.)--Virginia Polytechnic Institute and State University, 1992. / Vita. Abstract. Includes bibliographical references (leaves 207-209). Also available via the Internet.