Thesis (M.S. in molecular plant sciences)--Washington State University, December 2009. / Title from PDF title page (viewed on Jan. 8, 2010). "Program in Molecular Plant Sciences." Includes bibliographical references (p. 61-68).

Thesis (Ph.D.) -- University of Texas at Arlington, 2008.

Thesis (M. Phil.)--University of Hong Kong, 1989.

Thesis (M. Phil.)--University of Hong Kong, 1978. / Xoerx copy from typescript.

Quinine is an alkaloid natural product isolated from the bark of the cinchona tree. It has long served as a synthetic target due to its antimalarial properties. The total synthesis of quinine can be envisioned employing a recently developed catalytic enone cycloallylation methodology. This new process merges phosphine organocatalysis and transition metal catalysis. The pursuit of quinine details the first application of this novel method in organic synthesis. Herein, phosphine-catalyzed transformations of [alpha, beta]-unsaturated compounds as well as a historical overview of the alkaloid target are thoroughly reviewed. The following chapters discuss both racemic and asymmetric approaches toward quinine, including the completion of a formal synthesis. Not only has the cycloallylation proved successful in this synthetic application, but this body of work has seen the development of many highly selective transformations. / text

Not available / text

published_or_final_version / Chemistry / Master / Master of Philosophy

published_or_final_version / Chemistry / Master / Master of Philosophy

published_or_final_version / Chemistry / Doctoral / Doctor of Philosophy

No description available.