Dissertation (Ph.D.)--University of South Florida, 2008. / Includes vita. Includes bibliographical references. Also available online.

Diss. (sammanfattning) Linköping : Linköpings universitet, 2006. / Härtill 4 uppsatser.

Thesis (Ph. D.)--University of Alabama at Birmingham, 2008. / Title from first page of PDF file (viewed Feb. 13, 2009). Includes bibliographical references.

Thesis (M.S.P.H.)--University of Michigan, 1942.

Thesis (M.S.P.H.)--University of Michigan, 1942.

Thesis--University of Oklahoma. / Bibliography: leaves 154-165.

Thesis (M.S.P.H.)--Uniformed Services University of the Health Sciences, 2006 / Typescript (photocopy)

When formulating an estimate of event time, the human sensory system has been shown to possess a degree of perceptual flexibility. Specifically, the perceived relative timing of auditory and visual stimuli is, to some extent, a product of recent experience. It has been suggested that this form of sensory recalibration may be peculiar to the audiovisual domain. Here we investigate how adaptation to sensory asynchrony influences the perceived temporal order of audiovisual, audiotactile and visuotactile stimulus pairs. Our data show that a brief period of repeated exposure to asynchrony in any of these sensory pairings results in marked changes in subsequent temporal order judgments: the point of perceived simultaneity shifts toward the level of adaptation asynchrony. We find that the size and nature of this shift is very similar in all three pairings and that sensitivity to asynchrony is unaffected by the adaptation process. In light of these findings we suggest that a single supramodal mechanism may be responsible for the observed recalibration of multisensory perceived time.

No / Previously, dose emission below 30 L min(-1) through DPI has not been routinely determined. However, during routine use some patients do not achieve 30 L min(-1) inhalation flows. Hence, the aim of the present study was to determine dose emission characteristics for low inhalation flows from terbutaline sulphate Turbuhaler. Total emitted dose (TED), fine particle dose (FPD) and mass median aerodynamic diameter (MMAD) of terbutaline sulphate Turbuhaler were determined using inhalation flows of 10-60 L min(-1) and inhaled volume of 4 L. TED and FPD increase significantly with the increase of inhalation flows (p <0.05). Flows had more pronounced effect on FPD than TED, thus, faster inhalation increases respirable amount more than it increases emitted dose. MMAD increases with decrease of inhalation flow until flow of 20L min(-1) then it decreases. In vitro flow dependent dose emission has been demonstrated previously for Turbuhaler for flow rates above 30 L min(-1) but is more pronounced below this flow. Minimal FPD below 30 L min(-1) suggests that during routine use at this flow rate most of emitted dose will impact in mouth. Flow dependent dose emission results suggest that Pharmacopoeias should consider the use variety of inhalation flows rather than one that is equivalent to pressure drop of 4 KPa.

Objectives: The objective of this thesis is to explore the association between delayed rapid response team activation and patient mortality and morbidity in adult in-patients. Methods: Study 1 presents a protocol for a systematic review of literature regarding the association of delayed activation of rapid response teams and patient outcomes. Study 2 contains the results of the conducted systematic review, performing a search of the literature to critically appraise, aggregate, and present a narrative synthesis of included studies. The final study examines the association between delayed rapid response team activation and hospital mortality, ICU transfer, and cardiopulmonary arrest risk in a retrospective observational cohort study conducted as part of the “Hospital without Code Blues” initiative at Hamilton Health Sciences. Results: Studies included in the systematic review report an association between delayed activation and patient mortality and ICU transfer odds. Results of study three find that these delays may not be associated with patient mortality, but are significantly associated with ICU transfer events and a composite outcome of patient in-hospital mortality, ICU transfer, and cardiopulmonary arrest. Overall, patients experiencing a delayed rapid response team activation were at greater odds of experiencing a negative event during their course of stay in hospital. Conclusions: This thesis presents findings that suggest delayed activation of rapid response teams is associated with an increase in patient mortality and ICU transfers. Increased durations of delay are associated with increased odds of experiencing the above events. / Thesis / Master of Science (MSc)