Habil.-Schrift, Univ. Bern, 1997. / Literaturverz.

Diss. Univ. Zürich, 2009.

Habilitationsschrift--Hamburg. / In German with summary in English and German. Includes bibliographical references (p. 235-264) and index.

Thesis--University of Lund. / Extra t.p. with thesis statement inserted. Includes reprints of author's articles. Includes bibliographical references.

Thesis (doctoral)--Lund University, 1994. / Added t.p. with thesis statement inserted.

Thesis (doctoral)--Lund University, 1994. / Added t.p. with thesis statement inserted.

Thesis (doctoral)--Westphalia, 1934.

Thesis (doctoral)--Lund University, 1991. / Added t.p. with thesis statement inserted.

Thesis (Ph. D.)--University of Washington, 2000. / Vita. Includes bibliographical references (leaves 146-164).

nÃo hà / Introdução: O cÃncer Ãum dos principais problemas mundiais de saÃde e uma das causas mais importantes de morbidade e mortalidade em saÃde pÃblica. Segundo a OrganizaÃÃo Mundial de SaÃde (OMS) Ãa segunda causa de morte no mundo;perdendo apenas para as doenÃas cardiovasculares.Temos alta incidÃncia nacional de pacientes com cÃncer de pulmÃo avanÃado. Hà imprevisibilidade de perfis epidemiolÃgicos e respostas terapÃuticas. A biologia molecular tem sido importante na caracterizaÃÃo sobre a diferenciaÃÃo tumoral e prognÃstico da doenÃa.Novos tratamentos sÃo direcionados por caracterÃsticas farmacogenÃmicas. Pouco se sabe sobre a prevalÃncia desses genes no CearÃe na AmÃrica Latina, bem como sobre caracterÃsticas clÃnicas e desfechos relacionados. Objetivo: Identificar as caracterÃsticas e distribuiÃÃo do perfil epidemiolÃgico dos pacientes portadores de neoplasia de pulmÃo avanÃado, atendidos no ambulatÃrio de oncologia do Hospital de Messejana - Dr. Carlos Alberto Studart. Material e Métodos: Estudo observacional, prospectivo e analítico com inclusão de 135 pacientes portadores de neoplasia de pulmÃo avanÃado, entre 08/2012 a 12/2014; sendo analisados quanto a distribuiÃÃo de frequÃncia por procedÃncia, sexo, raÃa, escolaridade, queixas clinicas, tabagismo e perfil molecular. Resultados: Houve predominÃncia na procedÃncia de pacientes oriundos de cidades do interior do Cearà (69%); pacientes do sexo feminino (51,1%), baixa escolaridade (1o grau ou menos -19%), agricultores (22,4%), Pardos (47,4%) e tabagistas.(79%)O subtipo histolÃgico adenocarcinoma foi predominante (32,5%). DispnÃia foi a principal queixa clinica. O atendimento inicial predominante se deu no perÃodo de internamento (75,5%). Conclusão: Neste grupo de pacientes identificou-se um perfil de caracterÃsticas epidemiolÃgicas prÃprias. Criou-se um registro de cÃncer do hospital.Hà proporcionalidade de resultados com a literatura. / Introduction: Cancer is a leading global health problems and one of the most important causes of morbidity and mortality in public health. According to the World Health Organization (WHO) is the second leading cause of death worldwide, second only to the diseases cardiovasculares.Temos national high incidence of patients with advanced lung cancer. There unpredictability of epidemiological profiles and therapeutic responses. Molecular biology has been important in the characterization of tumor differentiation and prognosis of the disease. New treatments are directed by pharmacogenomic characteristics. Little is known about the prevalence of these genes in CearÃand Latin America as well as on clinical characteristics and outcomes related. Objective: To identify the characteristics and distribution of the epidemiological profile of patients with advanced lung cancer, treated at the oncology clinic at the Messejana Hospital - Dr. Carlos Alberto Studart. Material and Methods: An observational, prospective and analytical study with inclusion of 135 patients with advanced lung cancer, between 08/2012 to 12/2014; being analyzed for the distribution of origin by frequency, sex, race, education, clinical complaints, smoking and molecular profile. Results: There was a predominance in the success of patients from small towns of CearÃ(69%); female patients (51.1%), low education (first degree or less -19%), farmers (22.4%), Pardos (47.4%) and smokers. (79%) The histological subtype was adenocarcinoma predominantly (32.5%). Dyspnea was the main complaint clinica.O predominant initial treatment occurred in hospital stay (75.5%). Conclusion: In this group of patients identified a profile of epidemiological characteristics. Created a hospital cancer registry. There proportionality results with the literature.