Thesis (M.S. )--University of Tennessee Health Science Center, 1999 / Title from title page screen (viewed on July 16, 2008). Research advisor: Eugene C. Eckstein. Document formatted into pages (91 p. : ill.). Vita. Abstract. Includes bibliographical references (p. 73-77).

Thesis (Ph. D.)--Civil and Environmental Engineering, Georgia Institute of Technology, 2005. / Yoganathan, Ajit, Committee Member ; Sturm, Terry, Committee Member ; Webster, Donald, Committee Member ; Roberts, Philip, Committee Member ; Sotiropoulos, Fotis, Committee Chair ; Fritz, Hermann, Committee Member. Includes bibliographical references.

Thesis (Ph. D.)--Rutgers University, 2008. / "Graduate Program in Mechanical and Aerospace Engineering." Includes bibliographical references (p. 163-174).

Thesis--Lund. / Bibliography: p. 117-121.

Thesis (Ph. D.)--Ohio State University, 2009. / Title from first page of PDF file. Includes vita. Includes bibliographical references (p. 113-121).

Thesis (M.S.)--Brigham Young University. Dept. of Statistics, 2005. / Includes bibliographical references (p. 63-64).

Thesis (doctoral)--Københavns Universitet. / Summary in Danish.

Thesis (Ph. D.)--University of Alabama at Birmingham, 2006. / Description based on contents viewed Jan. 26, 2007; title from title screen. Includes bibliographical references (p. 112-126).

xvii, 168 p. : ill. A print copy of this thesis is available through the UO Libraries. Search the library catalog for the location and call number. / An acute bout of moderate-intensity dynamic exercise results in a sustained rise in skeletal muscle blood flow from that of pre-exercise levels. This postexercise skeletal muscle hyperemia is mediated by two histamine receptors (subtypes, H 1 and H 2 ). Skeletal muscle glucose uptake is also enhanced, in an insulin-independent manner, following moderate-intensity dynamic exercise. The impact of skeletal muscle hyperemia on glucose regulation following exercise has yet to be examined. Therefore, the purpose of this dissertation was to determine if postexercise skeletal muscle hyperemia plays a substantial role in glucose regulation in humans. In Chapter III I tested my ability to block local H 1 - and H 2 -receptors located in the vastus lateralis muscle in humans. The results demonstrate that I was able to successfully block the increase in local blood flow evoked by compound 48-80 with the combination of the H 1 -receptor antagonist pyrilamine and the H 2 -receptor antagonist cimetidine, administered via skeletal muscle microdialysis. In Chapter IV I sought to determine the effect of local combined H 1 - and H 2 -receptor blockade, administered via skeletal muscle microdialysis, on postexercise interstitial glucose concentrations. My findings indicate postexercise delivery of glucose to the interstitial space of the previously active skeletal muscle is mediated, in part, by local H 1 - and H 2 -receptors. In Chapter V I examined the effect of oral administration of H 1 - and H 2 -receptor antagonists on glucose regulation following a postexercise oral glucose load. The results showed that the glycemic and insulin responses to postexercise oral glucose load were more sustained with H 1 - and H 2 -receptor blockade versus control, suggesting a histaminergic effect on postexercise glucose regulation. / Adviser: John Halliwill

In this thesis, a parallel solver was developed for the modelling of blood flow through a number of patient-specific geometries. A locally conservative Galerkin (LCG) spatial discretisation was applied along with an artificial compressibility and characteristic based split (CBS) scheme to solve the 3D incompressible Navier-Stokes equations. The Spalart-Allmaras one equation turbulence model was also optionally employed. The solver was constructed using FORTRAN and the Message Passing Interface (MPI). Parallel testing demonstrated linear or better than linear speedup on hybrid patient-specific meshes. These meshes were unstructured with structured boundary layers. From the parallel testing it is clear that the significance of inter-processor communication is negligible in a three dimensional case. Preliminary tests on a short patient-specific carotid geometry demonstrated the need for ten or more boundary layer meshes in order to sufficiently resolve the peak wall shear stress (WSS) along with the peak time-averaged WSS. A time sensitivity study was also undertaken along with the assessment of the order of the real time step term. Three backward difference formulae (BDF) were tested and no significant difference between them was detected. Significant speedup was possible as the order of time discretisation increased however, making the choice of BDF important in producing a timely solution. Followed by the preliminary investigation, four more carotid geometries were investigated in detail. A total of six haemodynamic wall parameters have been brought together to analyse the regions of possible atherogenesis within each carotid. The investigations revealed that geometry plays an overriding influence on the wall parameter distribution. Each carotid artery displayed high time-averaged WSS at the apex, although the value increased significantly with a proximal stenosis. Two out of four meshes contained a region of low time-averaged WSS distal to the flow divider and within the largest connecting artery (internal or external carotid artery), indicating a potential region of atherosclerosis plaque formation. The remaining two meshes already had a stenosis in the corresponding region. This is in excellent agreement with other established works. From the investigations, it is apparent that a classification system of stenosis severity may be possible with potential application as a clinical diagnosis aid. Finally, the flow within a thoracic aortic aneurysm was investigated in order to assess the influence of a proximal folded neck. The folded neck had a significant effect on the wall shear stress, increasing by up to 250% over an artificially smoothed neck. High wall shear stresses may be linked to aneurysm rupture. Being proximal to the aneurysm, this indicated that local geometry should be taken into account when assessing the rupture potential of an aneurysm.