yes / Purpose: Inter-individual variance in optic nerve head (ONH) position, axial length and location of the temporal raphe suggest that customizing mapping between visual field locations and optic nerve head sectors for individuals may be clinically useful. Here we quantify the proportion of the population predicted to have structure-function mappings that markedly deviate from “average”, and thus would benefit from customized mapping. Design: Database study and case report Participants: Population database of 2836 eyes from the Beijing Eye Study; single case report of an individual with primary open angle glaucoma Methods: Using the morphometric fundus data of the Beijing Eye Study on 2836 eyes and applying a recently developed model based on axial length and ONH position relative to the fovea, we determined for each measurement location in the 24-2 Humphrey visual field the proportion of eyes for which, in the customized approach as compared to the generalized approach, the mapped ONH sector was shifted into a different sector. We determined the proportion of eyes for which the mapped ONH location was shifted by 15°, 30° or 60°. Main outcome measures: Mapping correspondence between locations in visual field space to localized sectors on the optic nerve head Results: The largest inter-individual differences in mapping are in the nasal step region where the same visual field location can map to either the superior or inferior ONH depending on other anatomical features. For these visual field locations, approximately 12% of eyes showed a mapping opposite to conventional expectations. Conclusions: Anatomically customised mapping shifts the map markedly in approximately 12% of the general population in the nasal step region where visual field locations can map to the opposite pole of the ONH than conventionally considered. Early glaucomatous damage commonly affects this region, hence individually matching structure to function may prove clinically useful for the diagnosis and monitoring of progression within individuals. / Australian Research Council Linkage Project 130100055 (industry partner, Heidelberg Engineering, GmBH, Germany).

[pt] Uma das estratégias mais populares para publicar dados estruturados na Web é expor bases de dados relacionais (BDR) em formato RDF. Esse processo é chamado BDR-para-RDF ou triplificação. Além disto, princípios de Linked Data oferecem vários guias para dar suporte a este processo. Existem duas principais abordagens para mapear bases de dados relacionais para RDF: (1) a abordagem de mapeamento direto, onde o esquema das bases de dados é diretamente mapeado para um esquema RDF, e (2) a abordagem de mapeamento customizado, onde o esquema RDF pode ser significativamente diferente do esquema original da base de dados relacional. Em ambas abordagens, existem vários desafios relacionados tanto com a publicação quanto com o uso de dados em RDF originados de bases de dados relacionais. Esta tese propõe a coleta de design rationale como uma valiosa fonte de informação para minimizar os desafios do processo de triplificação. Essencialmente, a coleta de design rationale melhora a consciência sobre as ações feitas no mapeamento da base de dados relacional para um conjunto de dados no formato RDF. As principais contribuições da tese são: (1) um modelo de design rationale (DR) adequado para o processo de BDR-para- RDF, independente da abordagem utilizada (direta ou customizada); (2) a integração de um modelo de DR para um processo que segue a abordagem direta de BDR-para-RDF e para um processo que segue a abordagem customizada usando a linguagem R2RML; (3) o uso do DR coletado para melhorar recomendações de reuso de vocabulários existentes através de algoritmos de Ontology Matching. / [en] One of the most popular strategies to publish structured data on the Web is to expose relational databases (RDB) in the RDF format. This process is called in RDB-to-RDF or triplification. Furthermore, the Linked Data principles offer useful guidelines for this process. Broadly stated, there are two main approaches to map relational databases into RDF: (1) the direct mapping approach, where the database schema is directly mapped to an RDF schema; and (2) the customized mapping approach, where the RDF schema may significantly differ from the original database schema. In both approaches, there are challenges related to the publication and to the consumption of the published data. This thesis proposes the capture of design rationale as a valuable source of information to minimize the challenges in RDB-to-RDF processes. Essentially, the capture of design rationale increases the awareness about the actions taken over the relational database to map it as an RDF dataset. The main contributions of this thesis are: (1) a design rationale (DR) model adequate to RDB-to-RDF processes, independently of the approach (direct or customized) followed; (2) the integration of a DR model in an RDB-to-RDF direct mapping process and in an RDB-to-RDF customized mapping process using the R2RML language; (3) the use of the DR captured to improve the recommendations for vocabularies to reuse.