Thesis (M.D.)--University of Hong Kong, 1972. / Also available in print.

Thesis (M.A.)--Scarman Centre for the Study of Public Order, University of Leicester in association with School of Professional and Continuing Education, University of Hong Kong, 1999. / Includes bibliographical references (leaves 59-61) Also available in print.

The abuse of narcotic drugs is an international problem in almost every respect, and as such requires international solutions. This thesis deals with both these questions. Since the last century, when the Sino-Indian opium trade thrived, the international trade in drugs has been of concern to the international community. After an introduction to the various types of narcotics and their properties, the history of drugs is reviewed, specifically with an eye to determining the factors which led to the creation of the international anti-narcotics movement. The international conferences on this subject, beginning with the Shanghai Opium Commission of 1909 and the Hague Opium Conferences several years later, were plagued with difficulties and conflicting objectives among the participants. The narcotics diplomacy which preceded the Second World War paved the way for current international action, but it also illustrated the problems inherent in international regulation. The modern drug problem, chiefly the abuse of heroin, is studiad and seen to be even more global than was the pre-World War II narcotics trade. The involvement of a greater number of states, both directly and indirectly, in the illicit drug traffic has been a stimulus to more vigorous international controls, but at the same time it has proved more difficult to enforce existing agreements throughout the international system. To an extent these difficulties can be attributed to the nature of the problem itself, as well as to conditions existing in a number of states, but essentially it would seem that the illicit narcotics trade continues to flourish because of the nature of the international system in which it operates. Thus a paradox can be seen the drug problem cannot be solved on a purely national level and hence international solutions must be adopted, but these solutions are also fated to face obstacles from the very start. / Arts, Faculty of / Political Science, Department of / Graduate

Thesis (Ph. D.)--University of Hong Kong, 2008. / Also available online.

Thesis (LL. M.)--York University, 2000. Graduate Programme in Law. / Typescript. Includes bibliographical references (leaves 156-168). Also available on the Internet. MODE OF ACCESS via web browser by entering the following URL: http://wwwlib.umi.com/cr/yorku/fullcit?pMQ56200.

published_or_final_version / Medicine / Master / Doctor of Medicine

The aim of this study was to investigate the induction of CYP1A by DMSO, to determine whether DMSO induced other P450 isozymes (CYP2B) and to compare the effects of DMSO and another differentiating agent, sodium butyrate. Induction of CYP1A-dependent ethoxyresorufin-O-deethylase (EROD) was observed in the presence of increasing concentrations of DMSO. All concentration investigated (1%, 1.5% and 2%) caused induction (2-3 fold), and enhanced BA-induction of EROD. Enhancement of BA-induction was greater with 1% and 1.5% DMSO (2.5-3 fold over BA alone) than with 2% (1.8-fold). DMSO alone did not increase CYP1A1 RNA levels. Hepatocytes treated with BA and DMSO together exhibited a 1.3-fold greater increase in RNA levels than with BA alone. Western blotting indicated that CYP1A1 protein was increased by inducers (BA, DMSO and isosafrole), but that CYP1A2 was not. This indicates that the CYP1A1 isozyme is responsible for EROD activity in these cultures, and that the CYP1A2-induction mechanism is lost in rat hepatocytes cultured under the conditions of these experiments. This observation was confirmed by the lack of CYP1A2-dependent phenacetin-O-deethylase (POD) activity in culture. The substituted benzimidazole omeprazole has been shown to induce CYP1A isozymes in human hepatocyte cultures. In this study omeprazole was not effective in inducing EROD activity in rat hepatocytes or <I>in vivo</I> in the rat. This confirms that rat hepatocytes are not a good model for CYP1A induction in man. DMSO appears to be isozyme specific, since CYP2B-dependent pentoxyresorufin-O-dealkylase (PROD) activity was not increased by DMSO, and phenobarbitone (PB) induction of PROD was enhanced only slightly by DMSO on day 3 of culture (4-fold over control; 1.5-fold over PB alone). Sodium butyrate and DMSO were both shown to induce differentiation of rat hepatocyte, with maintenance of low level of γ-glutamyl transferase activity, and maintenance of a more rounded morphology.

Thesis (Ph. D.)--University of Hong Kong, 2000. / Includes bibliographical references (leaves 401-434).

Introduction 1. Definition of the basic terms 2. Characterization of different types of illegal drugs 3. Drugs as a global problem 4. Drug crimes 5. Historical development of penal law regulation in the Czech Republic 6. Current penal law regulation 7. Alternative forms of dealing with crimes of addicted persons 8. Drug policy in the Czech Republic 9. Today s drug scene all over the Europe and in the Czech Republic Conclusion Abbreviation list Used literature list Appendix list Appendix Summary

Ph.D., Faculty of Health Sciences. University of the Witwatersrand, 2011