Thesis (M.S.W.)--University of Hong Kong, 1979.

Thesis (M.S.)--Worcester Polytechnic Institute. / Keywords: mass balance approach; bioavailability; drug delivery; dynamic modeling; partial differential equations; sensitivity analysis; dynamic simulations. Includes bibliographical references (p. 62-67).

Background This paper provides an updated review of the literature on drug prevention programmes (from 2001 to July2011) and reports the findings from these previous studies on the effectiveness and nature of present drug prevention practices. Relevant data on the effectiveness of drug prevention intervention among adolescents has been summarised and examined. In addition, this paper identifies various essential elements that have the potential for creating and providing effective drug prevention strategies, whether to prevent substance misuse or to minimise the harm caused. Different prevention strategies will also be discussed, including: social influence approach, refusal skill training, and motivational interviewing. Design The paper will conduct a review of the previous literature. Aims This literature review proposes to: 1. Review all of the published evidence from research which was conducted between 2001and 2011 on the effectiveness of drug prevention programmes for adolescents. 2. Identify findings and recommendations regarding the content, approaches, format, theoretical bases, and methods associated with an effective drug prevention program. 3. Discuss any potential or proved effective components on a drug prevention program in tackling such drug abuse problems. Methods Two searching engines (i.e. PubMed and Medline) were used to find the relevant papers and journals which have been published within the past ten years (i.e. 2001 to 2011). Studies about the evaluation of the effectiveness of drug education and prevention strategies, targeting the most vulnerable group (i.e. aged between 12 and 25) were included. Results Twenty four studies met the criteria and were reviewed in depth. Thirteen of them evaluated the effectiveness of school-based interventions, including the school-based drug testing program. The remaining papers evaluated the effectiveness of non-school based prevention interventions in different approaches such as social influence, parental cooperation, refusal skills education, and life skills training. Conclusions Social influence approaches were evidenced as the most effective intervention to prevent drug abuse. Interventions that are conducted interactively (e.g. simulated scenario and role-playing) are more effective than providing normative information. Gender differences were found in some of the interventions. However, it is recommended that further research should be conducted to evaluate these results. / published_or_final_version / Public Health / Master / Master of Public Health

Tolerance to anesthetic drugs is mediated partially by homeostatic mechanisms that attempt to restore normal neural excitability. The BK-type Ca2+-activated K+ channel, encoded by the slo gene, plays an important role in this neural adaptation. In Drosophila, a single sedative dose of the organic solvent anesthetic benzyl alcohol induces dynamic spatiotemporal changes in histone H4 acetylation across the slo regulatory region and leads to slo induction and tolerance. Mutations ablating the expression of slo also block the acquisition of tolerance, whereas activating the expression of a slo transgene results in resistance to drug sedation. Moreover, artificially inducing histone acetylation with the histone deacetylase inhibitor causes similar acetylation changes, slo induction, and functional tolerance to the drug. Histone acetylation changes occur over two highly conserved non-coding DNA elements, 6b and 55b, of the slo control region. To investigate the function of these two elements, I generated individual knockout mutants by gene targeting. Both knockout alleles are backcrossed into the CS wild type background. The 6b element seems to repress slo induction after drug sedation, because the 6b knockout allele overreacts to the drug. Compared to the wild type, 6b knockout allele shows a much greater slo message induction after drug sedation, it also displays stronger enhancements in seizure susceptibility and following frequency. In addition, the 6b deletion causes a persistent tolerance for at least a month, while tolerance only lasts about 10 days in wild type flies. My investigation also indicates that the 55b element limits basal slo expression in muscle. Finally, to investigate if the particular histone acetylation spikes are required for drug-induced slo induction and tolerance, I tether the histone-modifying enzymes, HDAC or HAT, to the 6b and 55b DNA elements, respectively. I observe that the positioning of an HDAC on these two elements blocks drug-induced slo induction and the development of tolerance. Therefore, histone acetylation across slo control region is required for the activation of slo and the acquisition of tolerance. / text

published_or_final_version / Public Administration / Master / Master of Public Administration

published_or_final_version / Medicine / Master / Doctor of Medicine

published_or_final_version / abstract / toc / Clinical Psychology / Master / Master of Social Sciences

No description available.

No description available.

Thesis (Ph.D.)--University of Nebraska-Lincoln, 2007. / Title from title screen (site viewed Feb. 22, 2008). PDF text:123 p. : col. ill. ; 588 K. UMI publication number: AAT 3275070. Includes bibliographical references. Also available in microfilm and microfiche formats.