Thesis (M. A.)--University of North Carolina at Greensboro, 2006. / Title from PDF title page screen. Advisor: Robert R. Hunt; submitted to the Dept. of Psychology. Includes bibliographical references (p. 35-37).

Thesis (Ph. D.)--UCLA, 2009. / Vita. Description based on print version record. Includes bibliographical references.

Thesis (M.A.)--University of Missouri-Columbia, 2007. / The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from title screen of research.pdf file (viewed on October 23, 2007) Includes bibliographical references.

Prescription drug advertisements are commonly seen in magazines and on television, and as a result, the public is familiar with them. Many drug ads are targeted toward older adults, who tend to use more medications, because they suffer from more chronic conditions than younger adults. Nonetheless, the effectiveness of drug advertising at persuading older adults to ask physicians for specific medications remains uncertain. Older adults’ explicit memory for drug ads is poor, but their implicit memory for drug ads may be better. Therefore, older adults may be implicitly persuaded by drug ads even when they cannot explicitly remember seeing them. The current study measured implicit memory with an incidental ratings exercise and an indirect test of preference; explicit memory was measured with intentional studying and a direct test of recognition. The purposes of the study were to compare implicit and explicit memory for drug ads in older and younger adults, to determine whether age differences in memory are affected by salient information or anxiety, and to demonstrate that a test of implicit memory may be useful in estimating advertising effectiveness. The results showed no age difference for implicit memory for drug ads, but an age difference was found for explicit memory for drug ads. However, contrary to hypotheses, neither salient information nor anxiety had an effect on implicit or explicit memory. The results were consistent with previous research demonstrating implicit memory in the absence of explicit memory. Although older adults had slightly worse explicit memory, both implicit and explicit memory for drug ads was generally good in both groups. The results were also obtained within the everyday context of prescription drug advertising, which extends memory research to an important real-world setting. Ethical considerations for research on aging and advertising are discussed. Drug ads are designed to be persuasive, but ads should be carefully designed to inform consumers, rather than to manipulate them. The implicit memory manipulation succeeded in demonstrating that ads are persuasive, suggesting that a complete assessment of advertising effectiveness should include a test of implicit memory.

The astounding capacity for learning ranks among the nervous system’s most impressive features. This thesis comprises studies employing varied approaches to improve understanding, at the level of neural circuits, of the brain’s capacity for learning. The first part of the thesis contains investigations of hippocampal circuitry – both theoretical work and experimental work in the mouse Mus musculus – as a model system for declarative memory. To begin, Chapter 2 presents a theory of hippocampal memory storage and retrieval that reflects nonlinear dendritic processing within hippocampal pyramidal neurons. As a prelude to the experimental work that comprises the remainder of this part, Chapter 3 describes an open source software platform that we have developed for analysis of data acquired with in vivo Ca2+ imaging, the main experimental technique used throughout the remainder of this part of the thesis. As a first application of this technique, Chapter 4 characterizes the content of signaling at synapses between GABAergic neurons of the medial septum and interneurons in stratum oriens of hippocampal area CA1. Chapter 5 then combines these techniques with optogenetic, pharmacogenetic, and pharmacological manipulations to uncover inhibitory circuit mechanisms underlying fear learning. The second part of this thesis focuses on the cerebellum-like electrosensory lobe in the weakly electric mormyrid fish Gnathonemus petersii, as a model system for non-declarative memory. In Chapter 6, we study how short-duration EOD motor commands are recoded into a complex temporal basis in the granule cell layer, which can be used to cancel Purkinje-like cell firing to the longer duration and temporally varying EOD-driven sensory responses. In Chapter 7, we consider not only the temporal aspects of the granule cell code, but also the encoding of body position provided from proprioceptive and efference copy sources. Together these studies clarify how the cerebellum-like circuitry of the electrosensory lobe combines information of different forms and then uses this combined information to predict the complex dependence of sensory responses on body position and timing relative to electric organ discharge.

Thesis (Ph. D.)--University of Washington, 2001. / Vita. Includes bibliographical references (leaves 64-71).

Thesis (M.A.)--York University, 2004. Graduate Programme in Psychology. / Typescript. Includes bibliographical references (leaves 56-62). Also available on the Internet. MODE OF ACCESS via web browser by entering the following URL: http://wwwlib.umi.com/cr/yorku/fullcit?pMQ99301

Thesis (Ph. D.)--Illinois State University, 1998. / Title from title page screen, viewed July 14, 2006. Dissertation Committee: Jeff Laurent, Salvatore J. Catanzaro (co-chairs), Connie B. Horton, Alvin E. House. Includes bibliographical references (leaves 70-83) and abstract. Also available in print.

The medial temporal lobe supports the encoding of new facts and experiences, and organizes them so that we can infer relationships and make unique associations during new encounters. Evidence from studies on humans and animals suggest that the hippocampus is specifically required for our ability to form these internal representations of the world. The mechanism by which the hippocampus performs this function remains unclear, but electrophysiological recordings in the hippocampus support a general model. One component of this model suggests that the cortex represents places, times, and events separately, and then the hippocampus generates conjunctive representations that connect the three. According to this hypothesis, the hippocampus binds places and events to an existing relational structure. This dissertation explores how item and place associations develop within cortex, and then examines the relational structure that organizes these events within the hippocampus. The first study suggests that contrary to previous models, events and places are bound together outside of the hippocampus in the entorhinal cortex and perirhinal cortex. The second study shows that this relational scaffold may be embodied by a continually changing code that permits both the association and separation of information across the continuum of time. The final study suggests that the hippocampus and entorhinal cortex contain qualitatively different time codes that may act in a complementary fashion to bind events and places and relate them across time. Overall, these studies support a theory wherein time is encoded in a range of brain regions that also contain conjunctive item and position information. In these regions, conjunctive representations of items, places, and times are organized not only by their perceptual similarity but also their temporal proximity.

Considerable research has been carried out to establish a rodent model for the study of human memory, yet functional similarities between the species remain up for debate. The hippocampus, a region deep within the medial temporal lobe of the mammalian CNS, is critical for long-term episodic memory. Projections from the medial entorhinal cortex convey spatial/contextual information, while projections from the lateral entorhinal cortex convey item/object information to the hippocampus. The functional significance of these parallel projections to the rodent hippocampus has been suggested to support spatial processing, while the same projections to the human hippocampus support spatial and non-spatial memory. Discharging in a location-specific manner, hippocampal place cells contribute to spatial memory; however, evidence for neuronal correlates of non-spatial object memory has not been fully defined. The current experiments were designed to address the following questions, while utilizing electrophysiology, functional inactivation during a novel behavioral task, and immunohistochemistry. Is the memory for objects hippocampal-dependent, solely due to the location of the object, or are objects represented within hippocampal activity independent of location? To tease apart spatial and non-spatial processing by the hippocampus, the spatial aspects of 3D objects were enhanced by utilizing movement. A novel discriminatory avoidance task, Knowing Your Enemy, was adapted from an Enemy Avoidance task to test true object memory in mice. Current findings support the notion that object-associations acquisition depends upon a specific context. Retrieval of such object-associations is not context-dependent, yet remains sensitive to temporary inactivation of the CA1 region of the dorsal hippocampus. The avoidance impairments observed following hippocampal inactivation were shown to not be a result of reduced anxiety. Immunohistochemical marker expression suggests that the CA1 region was highly active during object exposures, yet the hippocampal system responded differentially to moving and to stationary objects. Recordings of CA1 neurons yielded non-bursting object-related activity during object exploration, and place cell activity remained unaffected in the presence of moving objects; supporting independent, yet simultaneous processing of spatial and non-spatial information within the hippocampus. Together, the current findings support the notion that the CA1 region of the rodent hippocampus processes object-related information, independent of spatial information. / Includes bibliography. / Dissertation (Ph.D.)--Florida Atlantic University, 2017. / FAU Electronic Theses and Dissertations Collection