The meaning of ‘home’ for older adults in long-term care (LTC) settings is not well understood. Furthermore, how living with cognitively impaired older adults may affect the meaning of ‘home’ is under researched. The goal of this study was to explore how living with cognitively impaired older adults affects the meaning of ‘home’ for cognitively well female older adults residing in LTC. A convenience sample of eleven female cognitively well older adults was selected from four LTC settings in Winnipeg, Manitoba, Canada. The eleven women were interviewed to determine their meaning of ‘home’ prior to and following placement in the LTC setting. Two key questions posed to the women were, “Do you consider (name of LTC setting) to be ‘home’?” and “How does living with confused people affect the meaning of home?” Eight of the women considered the LTC setting where they reside to be ‘home’. Nine of the women indicated that living with cognitively impaired older adults does not affect their meaning of ‘home’. These findings suggest two things. First, that most cognitively well female older adults create a new ‘home’ for themselves when they move to the LTC setting. Second, that many cognitively well female older adults demonstrate compassion and acceptance of living with fellow residents who have cognitive impairment and may exhibit disruptive behaviours.

No description available.

The meaning of ‘home’ for older adults in long-term care (LTC) settings is not well understood. Furthermore, how living with cognitively impaired older adults may affect the meaning of ‘home’ is under researched. The goal of this study was to explore how living with cognitively impaired older adults affects the meaning of ‘home’ for cognitively well female older adults residing in LTC. A convenience sample of eleven female cognitively well older adults was selected from four LTC settings in Winnipeg, Manitoba, Canada. The eleven women were interviewed to determine their meaning of ‘home’ prior to and following placement in the LTC setting. Two key questions posed to the women were, “Do you consider (name of LTC setting) to be ‘home’?” and “How does living with confused people affect the meaning of home?” Eight of the women considered the LTC setting where they reside to be ‘home’. Nine of the women indicated that living with cognitively impaired older adults does not affect their meaning of ‘home’. These findings suggest two things. First, that most cognitively well female older adults create a new ‘home’ for themselves when they move to the LTC setting. Second, that many cognitively well female older adults demonstrate compassion and acceptance of living with fellow residents who have cognitive impairment and may exhibit disruptive behaviours.

No description available.

No description available.

The HIV-1 Gag p24 protein contains the HLA class-1 B*2705 restricted epitope KK10, responses to which are associated with delayed progression. Data from in vitro proteasomal digestion studies from our group has shown the production of a number of C-terminally extended and truncated epitopes containing KK10, produced in far higher quantities during proteasomal digestion than this “optimal epitope” and that the amount of antigen made in proteasomal digestion is instrumental in determining the development of immunodominance. This work aims to characterise the contribution of these naturally processed epitope forms to the cellular immune response to this region. Further proteasomal digestion studies have shown that the common KK10 intra-epitope escape mutant sequences R132K and L136M have major effects on epitope production by the proteasome and that a range of short peptides containing the N-terminal of the KK10 sequence are produced in large quantities by the proteasome. Recognition of the KK10 epitope forms by HLA B*2705 HIV-1 patients were characterised ex vivo and show recognition of KK10 epitope forms somewhat independent of the presence of KK10 recognition, we also show cross-recognition between KK10 epitope forms by CD8+ T cells, as well as recognition by CD4+ T-cells. TCR from CD8+ T-cells specific for KK10 epitope forms were found to share common features in the HLA binding CDR hyper-variable loops. Structural studies of the HLA B*2705 molecules in complex with the KK10 epitope forms show a shared binding motif at the N-terminus, and to a lesser extent, the C-terminus of the binding groove which may facilitate cross-recognition of complexes. In addition these studies show a potentially novel binding mode for a 14mer peptide, and refolding of truncated KK10 peptides as short as a 4mer with the HLA B*2705 molecule (crystallisation with a 6mer peptide shown). This demonstrates previously unrecognised flexibility of the HLA class-1 to bind and present peptides of different lengths to T-cells. We show that these HLA B*2705 binding-capable truncated peptides do not induce a CD8+ T-cell response in HLA B*2705 HIV-1 patients and may be able to block CD8+ T-cell responses to the KK10 epitope. This might represent a novel form of viral CTL escape. In addition we observe the presence of KK10 flanking mutations in patient sequences and significant associations between the presence of intra-epitope escape mutations, KK10 recognition and patterns of escape in flanking sequences. Finally we note the reduction in binding of KIR3DL1 to KK10 epitope forms relative to the KK10 epitope-HLA B*2705 complex. The presence of HLA B*2705 and KIR3DL1 associate with improved disease course in HIV-1 though the mechanism through which this occurs has yet to be defined.

Thesis advisor: Bernard O'Brien / This study investigated factors which influenced stable, primary love relationships among twelve lesbian couples who had been together at least fifteen years and had not reared children together. Each participant was interviewed separately in a retrospective, semi-structured interview that assessed the impact of selected factors over the course of the relationship. Each factor was examined to determine its influence in the beginning phase of the relationship (the first 5 years), in the middle phase (5-10 years into the relationship), and most recently (beyond 10 years into the relationship). Interpersonal dynamics as well as the influences of culture, religion, values, finances, and social supports were explored to determine their impact on relationship stability. / Thesis (PhD) — Boston College, 1994. / Submitted to: Boston College. School of Education. / Discipline: Counseling, Developmental Psychology, and Research Methods.

<p>Benzodiazepines are drugs used to treat insomnia and anxiety. This group of drugs should be prescribed with the duty of care to the elderly because of it´s negative effects. Life expectancy is increasing because of the progress of drug development. Aging brings physical and psychological changes leading to changes in pharmacokinetic and pharmacodynamic features. Drug treatment is becoming increasingly widespread and contributes to the increasing number of interactions and complications for the elderly. The aim of the study was to illuminate the consequences of long-term use of benzodiazepines in the elderly. The study was conducted as a literature review based on 14 scientific articles that were analyzed. The result showed that the theme benzodiazepine use among the elderly could be divided into three categories; consequences out of long-term use, benzodiazepine users experiences and the nursing perspective. The category of impact out of long-term use of benzodiazepines revealed three sub-categories: physical consequences, psychological consequences and social consequences. Information and education to the elderly patients is important to make the elderly aware of the negative effects that may arise out of a long-term use of benzodiazepines. It is essential that nurses already in their basic education acquire more knowledge about benzodiazepine use among elderly in order to address these problems in the nursing care.</p>

Benzodiazepines are drugs used to treat insomnia and anxiety. This group of drugs should be prescribed with the duty of care to the elderly because of it´s negative effects. Life expectancy is increasing because of the progress of drug development. Aging brings physical and psychological changes leading to changes in pharmacokinetic and pharmacodynamic features. Drug treatment is becoming increasingly widespread and contributes to the increasing number of interactions and complications for the elderly. The aim of the study was to illuminate the consequences of long-term use of benzodiazepines in the elderly. The study was conducted as a literature review based on 14 scientific articles that were analyzed. The result showed that the theme benzodiazepine use among the elderly could be divided into three categories; consequences out of long-term use, benzodiazepine users experiences and the nursing perspective. The category of impact out of long-term use of benzodiazepines revealed three sub-categories: physical consequences, psychological consequences and social consequences. Information and education to the elderly patients is important to make the elderly aware of the negative effects that may arise out of a long-term use of benzodiazepines. It is essential that nurses already in their basic education acquire more knowledge about benzodiazepine use among elderly in order to address these problems in the nursing care.

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