Thesis (Ph. D.)--Worcester Polytechnic Institute. / Keywords: diffusion; tendon; NMR; fMRI. Includes bibliographical references (p. 172-179).

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Dissertation (Ph.D.).--University of Texas Graduate School of Biomedical Sciences at San Antonio, 2006. / Vita. Includes bibliographical references.

Thesis (Ph. D.)--University of Texas at Austin, 2003. / Supervisor: John T. Markert. Vita. Includes bibliographical references. Available also from UMI Company.

Thesis (Ph. D.)--University of Texas at Austin, 2005. / Vita. Includes bibliographical references.

The work described in this thesis deals mainly with aspects related to two- and three-dimensional NMR imaging. A detailed discussion on frequency-selective excitation using amplitude modulated rf pulses in relation to slice selection in NMR imaging has been presented. This includes the analysis and implementation of the method as well as illustrative experimental results. Several radiofrequency probe designs suitable for high field NMR imaging have been experimentally evaluated and their modification and construction are also described. The comparative results obtained indicate the merits and demerits of different designs and provide necessary guidelines for selecting the most suitable design depending on the application. Practical aspects of two- and three-dimensional imaging have been discussed and NMR images of several intact systems have been presented. Experimental methods which enable slice selection in the presence of chemically shifted species and two-dimensional chemical shift resolved imaging have "been described and illustrated using phantoms. The use of three-dimensional chemical shift resolved imaging as a potential method to map the pH and temperature distribution within an object has also been demonstrated. A preliminary investigation of the application of ³¹P NMR spectroscopy to study the biochemical transformations of the rat kidney during periods of ischemia and reperfusion has been presented. / Science, Faculty of / Chemistry, Department of / Graduate

Brain operates on a network level. Magnetic resonance imaging (MRI) provides structural and functional images noninvasively with large field of view and at high spatial resolution and thus assumes an extremely valuable role in studying brain networks. The objectives of this doctoral work were to develop and apply novel MRI methods on human and rodent brains, for in vivo and global assessments of functional brain networks at resting and task-evoked states. Firstly, the feasibility of passband balanced steady-state free precession (bSSFP) imaging for distortion-free and high-resolution resting-state fMRI (rsfMRI) was investigated. Resting-state networks (RSNs) derived from bSSFP images were shown spatially and spectrally comparable to those derived from conventional gradient-echo echo-planar imaging (GE-EPI) with considerable intra- and inter-subject reproducibility. High-resolution bSSFP corresponded well to the anatomical images, with RSNs exquisitely co-localized to gray matter. Furthermore, RSNs at areas of severe susceptibility were proved accessible including human anterior prefrontal cortex and rat piriform cortex. These findings demonstrated for the first time that passband bSSFP approach can be a promising alternative to GE-EPI for rsfMRI. It offers distortion-free and high-resolution RSNs and is potentially suited for high field studies. Secondly, to examine the macrovascular contributions to the spatial and spectral prosperities of resting-state networks, spin-echo echo-planar imaging (SE-EPI) with moderate diffusion weighting (DW) was proposed for rsfMRI. SE and DW suppressed the extravascular and intravascular contributions from macrovessels respectively. Significantly lower functional connectivity strength was observed in the posterior cingulate cortex of the default mode network derived from DW SE-EPI data comparing to that derived from SE-EPI, suggesting a confounding role played by the intravascular component from large veins, whereas no significant spectral difference was detected. Therefore, the DW SEEPI approach for rsfMRI may assist in better identifying and interpreting largescale brain networks with future improvement in temporal resolution by acceleration techniques and in sensitivity at higher field. Thirdly, rsfMRI was performed to evaluate the intrinsic functional networks in the corresponding anatomical visual brain connections traced by Mn-enhanced MRI (MEMRI). Strengths of resting-state functional connectivity appeared to couple with structural connectivity in MEMRI, demonstrating the sensitivity of these structural and functional connectivity MRI techniques for assessing the neuroarchitecture, neurophysiology and structural-functional relationships in the visual brain in vivo. Fourthly, the hypothesis that a regional activation identified via general linear model analysis of fMRI data reflects the summation of multiple distinct networks that carry different functional purposes was tested. Overlapping frontoparietal networks engaged in a simple single-digit multiplication task were found and their functional roles were evaluated through independent components analysis and contributive source analysis. Future studies incorporating different arithmetic tasks and resting state will shed more light upon how brain accomplishes arithmetic and more complex tasks in general. Lastly, benefiting from higher SNR, better spatial and temporal resolution at higher field, exploratory fMRI studies were conducted on rats at 7 T for in vivo assessments of 1) the effect of dark-rearing on postnatal visual development, 2) sound amplitude modulations and 3) sound frequency modulation sweep direction selectivity in auditory system. ( / published_or_final_version / Electrical and Electronic Engineering / Doctoral / Doctor of Philosophy

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