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No description available.

No description available.

No description available.

The Dandy-Walker syndrome (DWS) has been defined as a congenital malformation of the structures of the posterior fossa characterised by cystic dilatation of the fourth ventricle, hypoplasia of the cerebellar vermis, enlargement of the posterior fossa, atresia of the foramina of Luschke and Magendie and associated hydrocephalus. Since its initial description definitions have been modified to include findings encountered in a particular case or series of cases. This lack of uniformity of the diagnostic criteria has made the objective assessment of management and outcome difficult. It has also resulted in terms such as DandyWalker variant, mega cisterna pouch and prominent cisterna posterior fossa cysts which magna, magna, do not persistent Blake's being applied to fit in with the particular criteria used for the series described.

No description available.

A desire to study congenital malformations of the CNS originated several years ago. It was found necessary first to acquire sufficient knowledge of anatomy of the normal adult human brain as well as of the morphogenesis of the developing human brain. The results of the work done in this field formed the subject for my M.Sc. thesis at the McGill University: Anatomical and Developmental Study of the Human Thalamus, 1951. This was subsequently published in the J. Comp. Neurology 1953 and 1954.

Many methods of gradually occluding blood vessels have been developed over the past Century. Some of these methods have withstood the effects of trial in time, and are still in use for clinical and experimental purposes. However, all of these methods have drawbacks of one sort or another. At present, there is need for a more efficient and less cumbersome means of occluding certain arteries for investigative and clinical purposes. One need has arisen from the desire to reproduce as realistically as possible many ominous disease states which result from aging and catastrophic vascular events.

Pavlov (1928) described the establishment of a conditioned salivary secretion to a non-specific stimulus as a “temporary connection” between the center responding to the conditioned stimulus (for example, the auditory "'center"' 'when a metronone was used) and that responding to the unconditioned stimulus, i.e. the “food center”. Since stimulation of the food center results normally in salivation, this same response may be produced by any stimulus which in turn activates the food center. A connection so formed is, in the true sense of Pavlov’s term, conditional.

Our clinical interest in the peripheral neuropathies has prompted the present study of metabolism of peripheral nerves. Our experiments were designed to investigate possible metabolic defects in various conditions of disturbed nerve function and to consider their relevance to clinical problems. As is well known, demyelinating lesions of nerves can be caused by a wide variety of etiological agents and conditions, resulting in fairly similar clinical disturbances. The mechanism by which interference with normal function occurs is not fully understood.