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Ginkgolides and bilobalide selectively regulate the expression of nitric oxide synthases麥偉基, Mak, Wai-kei. January 2000 (has links)
published_or_final_version / Medical Sciences / Master / Master of Medical Sciences
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Inhibitory effect of tetramethylpyrazine (TMP) on nitric oxide production in macrophages林浩強, Lam, Ho-keung. January 2001 (has links)
published_or_final_version / Medical Sciences / Master / Master of Medical Sciences
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The protective role of phenylaminoalkyl selenides against peroxynitrite-mediated reactionsDe Silva, Veronica 08 1900 (has links)
No description available.
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Mechanistic studies of S-nitrosothiol reactions with reference to potential physiological activityMcAninly, John January 1994 (has links)
A study of the reactions of various S-nitrosothiols, particularly S-nitroso-N- acetylpenicillamine (SNAP), was undertaken. These compounds were known to produce nitric oxide (NO) when decomposing, which has important and diverse biological roles. An example of their use in physiological research was demonstrated. The Griess method was used to determine the stoichiometry of nitrite production from S-nitrosothiol decomposition in various buffer solutions. In all cases the production was found to be almost quantitative. The kinetic measurement of SNAP decomposition in a variety of buffers and pH was undertaken. The results were complex and often erratic, conforming to first order but also half order kinetics in many cases. There was some indication that decomposition products and light could affect the reaction. The presence of disulphide (dimer) as a major reaction product was confirmed in the case of SNAP. Free-radical traps were used to probe the decomposition mechanism, as were hemin and haemoglobin as NO detectors to determine decomposition kinetics. The true agent of S-nitrosothiol decomposition was found to be intrinsic copper in the water supply and buffer salts. S-nitrosothiols were found to be stoichiometrically decomposed by Hg(^2+) ions, but catalytically decomposed by Cu(^2+) ions. Kinetic measurement confirmed the complex nature of the catalysis. The importance of SNO and NH(_2), and SNO and COO- as binding sites was demonstrated. Some explanation was found for the differing structure/reactivity relationships observed. It was shown that transnitrosation of a thiol could occur, involving thiolate anion attack upon the S-nitrosothiol. However, the reaction appeared to be very slow at physiological pH. The nitrosation of N-methylaniline by S-nitrosothiols was found to occur only in the presence of oxygen - direct transfer of NO did not occur, nitrosation being mediated after SNAP decomposition.
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Mechanistic studies of copper and thiolate ion induced S-nitrosothiol decompositionsDicks, Andrew P. January 1997 (has links)
A detailed study concerning the aqueous decomposition characteristics of S-nitrosothiols in both the presence and absence of cupric ions was undertaken. Spectrophotometric measurements established that the true catalytic species generating nitric oxide from S-nitrosothiols is Cu(^+), formed by the reduction of copper(II) ions by thiolate, which is present as an impurity in solution. Introduction of the specific cuprous ion chelator neocuproine inhibited reaction, with the concentration of thiol in situ having a significant influence on the absorbance/time traces obtained. Under certain conditions thiolate ions clearly promoted S-nitrosothiol decomposition, whereas at times an opposite effect was noted. These results have been correlated with the reductive ability and chelation properties towards Cu(^2+) of each thiol in question. Structure/reactivity studies were extended further to include a range of S-nitrosated aromatic and heterocyclic thiols which generated the corresponding disulfides in distilled water yet reformed the appropriate thione at pH 7.4, along with nitric oxide in both media. A mechanism has been proposed which accounts for these observations. The reaction of S-nitrosothiols with cupric ions bound to biologically significant molecules such as amino acids, peptides and proteins was followed. Despite Cu(^2+) being chelated in this manner, S-nitrosothiol decomposition was apparent, albeit at a slower rate than that seen when copper(II) sulfate pentahydrate was utilised. Thiolate ions were capable of reducing Cu(^2+) Cu(^+) which was bound to such molecules suggesting a possible mechanism for nitric oxide formation from S-nitrosothiols in vivo. The blue copper protein ceruloplasmin also promoted NO generation under physiological conditions. A brief investigation into the direct reaction of thiolate ion with its corresponding S-nitrosothiol was also carried out. It was discovered that the major reaction product in this instance is ammonia and not nitric oxide, suggesting that a different copper-ion independent process is occurring involving direct interaction between the two species.
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Influence of nitric oxide syntase inhibitors on the effects of ethanol after acute and chronic ethanol administration and withdrawal /Vassiljev, Vitali, January 1900 (has links) (PDF)
Thesis (D. Med. Sci.)--University of Tartu, 2004. / Vita. Includes bibliographical references.
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Ginkgolides and bilobalide selectively regulate the expression of nitric oxide synthases /Mak, Wai-kei. January 2000 (has links)
Thesis (M. Med. Sc.)--University of Hong Kong, 2000. / Includes bibliographical references (leaves 40-48).
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The oxidation of Ni(111) by energetic oxygen and nitric oxide adsorption studies on NiO(111)/Ni(111) /Zion, Benjamin David. January 2000 (has links)
Thesis (Ph. D.)--University of Chicago, Dept. of Chemistry. / Includes bibliographical references. Also available on the Internet.
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Ginkgolides and bilobalide selectively regulate the expression of nitric oxide synthasesMak, Wai-kei. January 2000 (has links)
Thesis (M.Med.Sc.)--University of Hong Kong, 2000. / Includes bibliographical references (leaves 40-48). Also available in print.
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Inhibitory effect of tetramethylpyrazine (TMP) on nitric oxide production in macrophagesLam, Ho-keung. January 2001 (has links)
Thesis (M.Med.Sc.)--University of Hong Kong, 2001. / Includes bibliographical references (leaves 43-65). Also available in print.
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