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Surface modification of polystyrene thin films was achieved using a plasma process with reactive gases to form functional groups. Advancing contact angles were measured after modification. Polystyrene surfaces were observed to reach a minimum average wetting contact angle of 7 degrees. The time required to achieve this contact angle decreased significantly by increasing the power of the discharge or by lowering the discharge source closer to the polymer substrate. Characterization studies of power, height, and corona exposure time versus contact angle led to the formation of surface energy gradients across the substrate. Photoluminescent tagging agents were used to quantify the degree of carboxyl modification achieved with water plasma and amine modification achieved with ammonia plasma. AMCA (7-amine-4-methyl coumarin hydrazide) was used to show that surface modification reaches a maximum functionalization before degradation of the polymer substrate occurs with water vapor. A parallel study with OPA (O-phthaldialdehyde) yielded similar results when ammonia was ionized over the surface. Additionally, stable surfaces were created by chemical reaction of zinc acetate with the freshly modified polymer. Zinc sulfide particles were formed within the polymer surface by reaction with hydrogen sulfide gas. Flourescence spectroscopy was used to verify the formation of zinc sulfide. / Master of Science

Mémoire numérisé par la Direction des bibliothèques de l'Université de Montréal.

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A statistical equilibrium theory is developed which characterizes the large-scale coherent structures that emerge during the course of the evolution of an ideal two-dimensional magnetofluid. Macrostates are defined to be local joint probability distributions, or Young measures, on the values of the fluctuating magnetic field and velocity field at each point in the spatial domain. The most probable macrostate is found by maximizing a Kullback-Liebler entropy functional subject to constraints dictated by the conserved integrals of the ideal dynamics. This maximum entropy macrostate is, for each point in the spatial domain, a Gaussian probability distribution, whose local mean is an exact stationary solution of the evolution equations of the magnetohydrodynamic system. The predictions of the statistical equilibrium model are found to be in excellent qualitative and quantitative agreement with recent high resolution numerical simulations of turbulence in slightly dissipative two-dimensional magnetofluids.

Yes / The plasma protein binding (PPB) of a drug plays a key role in both its pharmacokinetic and pharmacodynamic properties. During lead optimisation, medium and high throughput methods for the early determination of PPB can provide important information about potential PKPD profile within a chemotype or between different chemotype series. Diffusion ordered spectroscopy (DOSY) is an NMR spectroscopic technique that measures the diffusion of a molecule via applying varying magnetic field gradients, where the diffusion is primarily affected by its molecular size/weight and solution viscosity. Here, we describe the use of DOSY for a rapid and straight forward method to evaluate the PPB of drug molecules, using their binding to bovine serum albumin (BSA) as a model. / The full-text of this article will be released for public view at the end of the publisher embargo on 11 Jun 2025.