Adolescents and Young Adults (AYAs) ages 15-39 years with cancer have received little attention in the medical and health fields, resulting in a lack of progress for this age group. Little is known about the unique biologic, epidemiologic, and psychosocial issues that play an integral role in the AYA cancer journey. The purposes of this study were to use the Tennessee Cancer Registry for all new cancer cases from 2004-2008 to determine 1) the main types of cancer that affect AYAs in TN, 2) the predictors of late-stage diagnosis of melanoma, and 3) the factors that predict a total thyroidectomy for cancer treatment. A total of 8,097 cancer cases were diagnosed in AYAs in Tennessee from 2004-2008. The five main cancer types were breast cancers, melanomas, thyroid cancers, lymphomas, and testicular cancers and accounted for over 50% (N=4,269) of cancers in AYAs in Tennessee during the study period. Females were significantly more likely to be diagnosed with melanomas (age adjusted incidence rate (AIR) 14.01, 95% CI 12.96-15.06) and thyroid cancers (AIR 13.39, CI 12.37-14.42) compared to males (AIR 8.08, CI 7.28-8.88 and AIR 3.50, CI 2.98-4.03, respectively). All cancer types increased with age. Individuals with government insurance (OR 8.41, CI 3.04-23.27) and those 15-19 years of age (OR 6.30, CI 1.74-22.86) had the highest risk of late-stage melanoma. Significant predictors of a using total thyroidectomy for thyroid cancer treatment included regional/distant stage cancer at diagnosis (OR 2.80, CI 1.34-5.85) compared to localized stage, papillary carcinoma (OR 2.64, CI 1.02-6.83) and papillary adenocarcinoma (OR 3.56, CI1.37-9.19) histology types compared to follicular adenocarcinoma, and residence in non-Appalachian Tennessee (OR 2.07, CI 1.26-3.42) compared to Appalachian TN. An increased awareness of cancer types that affect AYAs in Tennessee will provide a basis for developing public health campaigns for cancer prevention and control in this population. This research serves as a first step in using state-based cancer registries to identify the unique characteristics of cancer in AYAs and will set the stage for future state-based research in this underserved population.

<p>Predmet doktorskog umetničkog rada &bdquo;Uloga sećanja u izgradnji identiteta&ldquo; je analiza procesa dramatizacije sećanja. Rad obuhvata teorijsko istraživanje sećanja, kao i načina za njegovu inscenaciju, s jedne strane, a sa druge umetničko istraživanje ličnog i kolektivnog sećanja povezanog s periodom odrastanja u specifičnom društvenom i istorijskom kontekstu Jugoslavije, prema kojem se, u datom trenutku, kroz pozorišnu predstavu, uspostavlja odnos.</p> / <p>The subject of doctoral art work &quot; Role of remembrance in identity formation&quot; is the analysis of the process of dramatization of memory. The thesis<br />includes theoretical research concerning memory, as well as the means for staging it, and, on the other hand - artistic research of the personal and collective memory connected to a period of growing up in a specific social and historical context of Yugoslavia towards which a relationship is established through a theater performance, at a specific given moment.</p>

Despite the hemispheric importance of Great Salt Lake (GSL) as a staging area for migratory birds, little is known about the resources that GSL provides to these birds, or how changes to the GSL ecosystem might impact the avian community. Three species of migratory waterbirds that stage at GSL are Wilson’s phalaropes (Phalaropus tricolor), red-necked phalaropes (Phalaropus lobatus), and eared grebes (Podiceps nigricollis). My objective for this research was to study the impacts of prey availability on the staging ecology of these species. In Chapter 2, I examined the use of GSL habitats by both species of phalaropes. In the high-salinity bays of GSL, phalaropes were most strongly associated with shallow water. In the low-salinity bay, there were no strong associations between phalarope presence and particular habitat characteristics. In Chapter 3, I analyzed the behaviors of phalaropes relative to prey densities. Phalaropes commonly foraged in Carrington Bay, which had the highest densities of brine fly (Ephydridae) adults, and in Farmington Bay, which had high densities of benthic macroinvertebrates. Foraging behavior differed between Wilson’s and red-necked phalaropes, with Wilson’s phalaropes spinning more often than red-necked phalaropes. In Chapter 4, I examined interannual and nightly variations in eared grebe fall migration departures in relation to prey availability and environmental conditions. Eared grebes began migration relatively early when lake temperatures were relatively warm, densities of brine shrimp (Artemia franciscana) adults were high, and densities of brine shrimp cysts were low. The likelihood that eared grebes would depart on a given night was positively associated with the average barometric pressure 12 hours prior to sunset. The resources provided by GSL support substantial proportions of the staging populations of phalaropes and eared grebes. Management efforts should seek to maintain the habitats and resources needed by phalaropes and eared grebes at GSL. Future large-scale diversions of freshwater may threaten GSL’s suitability as a staging area for these birds.

The diploma thesis concerns 1918-2017 stagings and adaptations of Strakonický dudák. We continue in the bachelor´s thesis Character of a bagpiper in 19th century Czech literature, a comparison with Pitinský's 2013 staging of Strakonický dudák. The aim of the diploma thesis is to show the changes in the attitude towards Tyl´s drama Strakonický dudák (1847) during the 20th and the beginning of the 21st century. On the basis of the interpretation of Tyl´s text we analyse chosen adaptations and stagings and we compare the main topics with Tyl´s version. In the first part we are concerned with interpretation of film adaptations of Tyl´s drama from 1937 to 1955. We examine different approaches to the theme and the way it is affected by socio-political situation. In the second part we deal with theatre stagings of Strakonický dudák. First, we deal with the position of theatre since the 1950s and with the demands on the adaptation on Tyl´s play. By means of interpretation of 1980-2006 stagings of Strakonický dudák we follow the shift from the adaptation based on Zdeněk Nejedlý´s thoughts to distinctive and original adaptations which offer current topics

BACKGROUND: MRI is increasingly being used for rectal cancer staging. The purpose of this study was to summarize published evidence to determine the accuracy of MRI for T-category, lymph node (LN) metastases, and circumferential resection margin (CRM) involvement in rectal cancer. METHODS: Sensitivity, specificity, and diagnostic odds ratios (DOR) were estimated using hierarchical summary receiver operating characteristics modeling and bivariate random effects modeling. RESULTS: MRI was more specific for CRM (94%, 95%CI 88-97) than for T-category (75%, 95%CI 68-80) and LN’s (71%, 95%CI 59-81) but was more sensitive for T-category (87%, 95%CI 81-92) than for CRM (77%, 95%CI 57-90) and LN’s (77%, 95%CI 69-84). DOR was higher for CRM (56.1, 95%CI 15.3-205.8) than for LN’s (8.3, 95%CI 4.6-14.7) and T-category (20.4, 95%CI 11.1-37.3). CONCLUSIONS: MRI has good accuracy for both CRM and T-category and should be considered for preoperative rectal cancer staging. In contrast, LN assessment is poor on MRI.

BACKGROUND: MRI is increasingly being used for rectal cancer staging. The purpose of this study was to summarize published evidence to determine the accuracy of MRI for T-category, lymph node (LN) metastases, and circumferential resection margin (CRM) involvement in rectal cancer. METHODS: Sensitivity, specificity, and diagnostic odds ratios (DOR) were estimated using hierarchical summary receiver operating characteristics modeling and bivariate random effects modeling. RESULTS: MRI was more specific for CRM (94%, 95%CI 88-97) than for T-category (75%, 95%CI 68-80) and LN’s (71%, 95%CI 59-81) but was more sensitive for T-category (87%, 95%CI 81-92) than for CRM (77%, 95%CI 57-90) and LN’s (77%, 95%CI 69-84). DOR was higher for CRM (56.1, 95%CI 15.3-205.8) than for LN’s (8.3, 95%CI 4.6-14.7) and T-category (20.4, 95%CI 11.1-37.3). CONCLUSIONS: MRI has good accuracy for both CRM and T-category and should be considered for preoperative rectal cancer staging. In contrast, LN assessment is poor on MRI.

This thesis establishes formal equational properties of multi-stage calculi and related proof techniques that support analyses of staged programs. A key promise of staging is to make programs efficient without destroying clarity, thereby reducing the likelihood of bugs. However, few publications rigorously verify that their staged programs indeed behave as intended. In fact, little is known about how staged programs can be verified, or what correctness issues staging introduces. To solve this problem, I show a reduction of the correctness of a staged program to that of an unstaged program. This reduction not only clarifies the effects of staging on program behavior but also eases verification, as unstaged programs are more susceptible to existing reasoning techniques. I also demonstrate that important single-stage reasoning techniques apply to staged programs. These techniques are useful for establishing side conditions for the reduction and for discovering or validating further reasoning principles. / NSF grant CCF-0747431

Background: GISTs are gastrointestinal mesenchymal tumours that express the type III receptor tyrosine kinase KIT. The KIT proto-oncogene encodes the receptor KIT. Most GISTs have gain-of-function mutations in the KIT or PDGFRA gene. The tyrosine kinase is therefore continuously activated leading to ligand-independent dimerization. Imatinib mesylate (Glivec®) is considered to be the first-line palliative treatment. The activated form of the KIT receptor tyrosine kinase is inhibited by imatinib. The aim of the study was to compare the survival of patients treated with either adjuvant or down-staging imatinib with historic controls treated with radical surgery (R0) only. Methods: A historic control group was chosen from a population-based series from western Sweden (population 1.6 million) that matched the adjuvant (n=23) and down-staging (n=7) groups respectively. Mutation analysis was performed in all cases with bidirectional direct sequencing. The recurrence-free survival was calculated. Results: There was only one recurrence (4 %) in the adjuvant group, and no recurrences in the down-staging study group, compared to 32/48 patients (67 %) in the control group. Tumour size decreased in diameter from 20 cm to 11 cm with down-staging treatment. Conclusion: Adjuvant imatinib improves recurrence-free survival in R0 resected patients. Down-staging treatment with imatinib is recommended for patients with large tumours or metastases. The importance of mutation analysis was established.

<p>Background: GISTs are gastrointestinal mesenchymal tumours that express the type III receptor tyrosine kinase KIT. The KIT proto-oncogene encodes the receptor KIT. Most GISTs have gain-of-function mutations in the KIT or PDGFRA gene. The tyrosine kinase is therefore continuously activated leading to ligand-independent dimerization. Imatinib mesylate (Glivec®) is considered to be the first-line palliative treatment. The activated form of the KIT receptor tyrosine kinase is inhibited by imatinib. The aim of the study was to compare the survival of patients treated with either adjuvant or down-staging imatinib with historic controls treated with radical surgery (R0) only.</p><p>Methods: A historic control group was chosen from a population-based series from western Sweden (population 1.6 million) that matched the adjuvant (n=23) and down-staging (n=7) groups respectively. Mutation analysis was performed in all cases with bidirectional direct sequencing. The recurrence-free survival was calculated.</p><p>Results: There was only one recurrence (4 %) in the adjuvant group, and no recurrences in the down-staging study group, compared to 32/48 patients (67 %) in the control group. Tumour size decreased in diameter from 20 cm to 11 cm with down-staging treatment.</p><p>Conclusion: Adjuvant imatinib improves recurrence-free survival in R0 resected patients. Down-staging treatment with imatinib is recommended for patients with large tumours or metastases. The importance of mutation analysis was established.</p>

In this thesis I investigate what ‘authenticity’ means in a contemporary popular context and how it is used in the staging of bodies. Furthermore, I analyse works of dance and fashion from the past fifteen years with a focus on their strategies of challenging the notion of ‘bodily authenticity’.   When ‘an authentic body’ is sought by participants or demanded by judges and ‘experts’ on popular makeover and casting TV shows such as The Swan (Fox 2004) or Germany’s Next Topmodel (Pro 7 2006-present) this refers to the physical visualisation of what is perceived/presented as the participants ‘inner self’. I scrutinise the staging techniques and the codes of appearance that bodies have to comply with in order to be deemed ‘authentic’ on the shows. To define them and place them in the history of the idea of ‘bodily authenticity’, I complement my study with an outline of how ‘authenticity’ was understood in the Enlightenment and what techniques were used to stage the body when the concept gained currency, for instance in the writings of Rousseau. My analysis makes clear that 'bodily authenticity' on the two TV shows is achieved by strictly following gender-normative codes of beauty and by a depiction of 'working hard'. But various techniques also mask the hard work, for example by showing a participant ‘having fun’ performing it.   Contemporary works of dance and fashion challenge the problematic implications in the notion of ‘bodily authenticity’. I analyse three strategies of undermining the ‘authentic’ ideal in a total of seven pieces. These strategies are hyperbole which exaggerates the beauty code implicit in ‘authentic appearance’; multiplicity which undermines ‘authenticity’s’ essentialism and estrangement which denies the notion of individual authorship. In conclusion, I place the staging strategies used in my examples in a wider cultural context and highlight potential problems inherent in their critiques. / <p>Thesis is done in ’co-tutelle’ with Freie Universität Berlin. </p>