No description available.

This study investigated the immunological aspects of Entamoeba histolytica infection in Syrian hamsters. Immunization of hamsters by an intradermal injection with live axenic amoebae, conferred complete protection against amoebic liver abscess. Protection was achieved with homologous or heterologous strains of E. histolytica and was dose-dependent. Combination of thymectomy and anti T-cell serum treatment significantly increased the size of liver abscess and metastatic dissemination of the parasite. It was shown that a cell-mediated immune response controls the healing of skin ulcers in vaccinated animals and thus confers on them resistance to intrahepatic amoebic challenge infection. Resistance to hepatic infection with E. histolytica can be passively transferred to normal recipients with sensitized cells, but not with immune serum. Sensitized cells from vaccinated, protected or infected animal kill E. histolytica trophozoites in vitro. Splenectomy reduces the resistance of hamsters to amoebic infection. It is suggested that macrophages are required in the host defence against the establishment of amoebic abscess in the liver and dissemination of amoebae to other organs.

Thesis (Ph.D.)--University of Adelaide, Dept. of Paediatrics, 2002? / Includes list of publications arising from the thesis. Bibliography: leaves 327-341.

Thèse (Ph. D.)--Université Laval, 2008. / Bibliogr. Publié aussi en version électronique dans la Collection Mémoires et thèses électroniques.

Thesis (M.A.)--Brigham Young University. Dept. of History. / Includes bibliographical references (leaves [175]-184).

No description available.

Ticks belong to the ectoparasites which are dangerous for the human beings because of the transmission of bacterial, viral, and protozoan pathogens. The development of a vaccine against tick is very important. Cystatins play important role in tick digestion and they have an immunomodulation effects. For this reason cystatins are possible candidates for this vaccines. This thesis focuses on experimental mice vaccination with recombinant cystatin from Ixodes ricinus.

Plague is a classic zoonosis caused by the bacterium Yersinia pestis and is subject to the International Health Regulations, 1969. In the last two millennia, plague has become widespread, with three pandemics occurring in the 6th, 14th and 20th centuries. Currently, plague outbreaks and epidemics still occur worldwide. This study attempts to develop formal work methods and procedures for plague surveillance and control by environmental health practitioners as a strategy to ensure that field data can be integrated within the municipal, provincial and national spheres of government. A qualitative, explorative, descriptive, inductive and deductive research design was followed. A documentary research approach was employed as the primary method of data collection. To obtain additional information, both semi-structured personal interviews and physical observations during plague surveillance were adopted by the researcher. The organisational structure of the health care system in South Africa was analysed to identify and explain the role and functions of relevant decision-makers related to the surveillance and control of plague within the different spheres of government. Legislative measures regarding plague surveillance and control were also presented. As a prerequisite for the development of work methods and procedures for plague surveillance and control, the epidemiology of plague was discussed with emphasis on the distribution and characteristics of the disease in South Africa. Important rodent reservoirs and flea vectors of plague in South Africa were identified. Clinical manifestations, diagnosis and treatment of plague were described and discussed. Within this qualitative study an attempt has been made to develop work methods (xiii) and procedures for plague surveillance and control in South Africa. Relevant field data forms to be used during plague surveillance and control strategies were also developed. Recommendations emanating from the study can be found in the final chapter.

Class of 2005 Abstract / Objectives: To quantify the initial short-term market response of product liability litigation in appellate courts against vaccine manufacturers between 1987 and 2003. Methods: This project used a retrospective data analysis. The study analyzed appellate court decision found searching the legal research section of Lexis-Nexis® between 1987 and 2003. A single index market model was used to examine an event window of (-1, +1) and calculate a cumulative abnormal return for one of three categories; outcome in favor of the plaintiff, outcome in favor of the defense, or case dismissal. Results: Overall, this study investigated vaccine-related litigation. Thirty-three lawsuits were found involving 12 separate parent companies and ultimately lead to 82 separate incidences. A majority of the cases involved litigation concerning thimerisol (n =12, 36%). Following inclusion and exclusion criteria for the appellate court rulings, 9 cases were in favor of plaintiff, 10 cases were in favor of the defense, and 14 cases were dismissed. Appellate rulings favoring the plaintiffs were found to be negative and statistically significant, with cumulative abnormal returns equaling -1.39% during the (-1,+1) event window (p < 0.05). The mean cumulative abnormal returns for rulings favoring the defense or case dismissals were statistically insignificant at 0.49% and -0.29%, respectively Implications: Product liability litigation against vaccine manufacturers can produce significant negative short-term security price returns, which can be a disincentive for corporations to invest in vaccine development and production.

Pneumonia is a common disease spread throughout the whole world. It appears within all age groups, however, the most endengered groups are the infants and seniors whose lives are more likely at risk. This final thesis compares direct costs of the preventative actions utilizing the Prevenar 13 vaccine and costs related to the ambulatory treatment and consequent care of the hospitalized patients. Calculations are based on anonymised data from an ambulant care and hospitalized patient treatments in hospital of Melnik town.