Spelling suggestions: "subject:"hydroxyaceto kersters, eynthesis"" "subject:"hydroxyaceto kersters, asynthesis""
1 |
Synthesis of Functionalized δ-Hydroxy-β-keto Esters and Evaluation of Their Anti-inflammatory PropertiesGrosse, Michel, Günther, Kerstin, Jordan, Paul M., Roman, Dávid, Werz, Oliver, Beemelmanns, Christine 27 July 2023 (has links)
δ-Hydroxy-β-keto esters and δ,β-dihydroxy esters are characteristic
structural motifs of statin-type natural products and drug
candidates. Here, we describe the synthesis of functionalized δ-
hydroxy-β-keto esters in good yields and excellent enantioselectivities
using Chan’s diene and modified Mukaiyama-aldol
reaction conditions. Diastereoselective reduction of δ,β-dihydroxy
esters afforded the respective syn- and anti-diols, and
saponification yielded the corresponding acids. All products
were evaluated for their anti-inflammatory properties, which
uncovered a surprising structure-activity relationship.
|
Page generated in 0.0656 seconds