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The Global ETD Search service is a free service for researchers
to find electronic theses and dissertations. This service is
provided by the
Networked Digital Library of Theses and Dissertations.
Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
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The role of the nucleus of the solitary tract in rats with activity-based anorexia / 活動性拒食症のラットにおける孤束核の役割について / カツドウセイ キョショクショウ ノ ラット ニオケル コソクカク ノ ヤクワリ ニツイテ石原 枝里子, Eriko Ishihara 17 September 2022 (has links)
活動性拒食症(ABA)とは、食事時間の制限と過剰なランニングによって引き起こされる摂食障害である。本論文では、ABAモデルラットが示す摂食障害に、脳の孤束核がどう関わっているかを検証した。第一実験は、筆者の立てた仮説に基づき、オピオイドの役割が中枢性か末梢性かについて、孤束核にナロキソンを直接投与し、その影響を調べた。第二実験では、第一実験の結果を踏まえ、ABAラットの孤束核を破壊し、その影響を調べた。 / Active anorexia (ABA) is an eating disorder caused by restricted meal times and excessive running. This study examined the involvement of the nucleus of the solitary tract (NST) of the brain in ABA model rats. In the first experiment, based on the hypothesis previously formulated by the author, naloxone was microinjected into the NST. This was to determine whether the opioid worked in the central or peripheral mechanisms. In the second experiment, based on the results of the first experiment, the NSTs of rats were lesioned and the effects were examined. / 博士(理学) / Doctor of Philosophy in Science / 同志社大学 / Doshisha University
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