Contract Research Organization (CRO) industry has been a fast growingservice sector within the pharmaceutical and biotechnology industry since the early 1980’s. Aiming at assisting its clients in obtaining product registration and market approval from the health authorities (i.e. Food and Drug Administration of the US and Department of Health of Taiwan), CRO’s provide extensive consultations as well as clinical research and management services, covering both pre-clinical and clinical arenas. In recent years, global CRO’s have been expanding towards the Southeastern Asian (thereafter “SEA”) region targeting, Singapore, Taiwan, Hong Kong, China, and South Korea. While most of the empirical research on market entry mode has targeted the manufacturing industries, more recent studies have been completed on service sectors targeting advertising and financing industries. Since the history of CRO is relatively short, limited study has been performed on this industry, especially on the international entry patterns and behaviors for the CRO industry. This research document examines the current environments of CRO industry in Taiwan and Singapore and the factors influencing international company’s decisions on the entry mode. A recommendation of the best options to enter Taiwan and Singapore for the international CRO’s is presented. The paper concludes with findings as well as recommendations for further investigation directions.