Note: / The presence of carotenoids in bacteria was demonstrated by Zopf in 1889, who designated this group of bacterial pigments lipochromes because of their solubility in the fat solvents. He demonstrated the presence of the carotenoids by means of the lipocyan reaction. This reaction is a color test for carotenoids and consist of adding concentrated sulfuric acid to an ethereal solution of the pigment and a positive test gives a deep indigo blue color.

Note: / The consistent isolation and accurate classification of the pathogenic anerobic Actinomyces from clinically and histopathologically diagnosed cases of “true” Actinomyces is not always possible. This, it is felt is due primarily to the lack of known differentiating characteristics of the so-called Smooth form of the etiological agent.

<p>Abstract</p><p>The envelope of Gram-negative bacteria is a tightly regulated, intricate system, and as an essential component of these species, it is often the target of antibacterial treatments. Bacteria monitor and protect their envelope through a multitude of distinct stress response pathways, each with its own specialized role in maintaining a functioning envelope. Although these response pathways are each specialized for a particular type of stress, they are co-regulated and act as a network of stress responses rather than isolated pathways. Studying these pathways, both individually and as a network, provides insight into bacterial survival and may aid the design of antimicrobials. In this work, envelope stress response pathways of Escherichia coli are explored to elucidate the activation mechanisms driving individual pathways and to describe the co-regulatory properties linking the pathways. The production of outer membrane vesicles is examined for an entire knock-out library using a new, high-throughput dot-blot method. Based on these data, novel biological pathways are implicated in the production of vesicles and the link between vesiculation and the SigmaE stress response pathway is investigated. Further experiments on the SigmaE pathway lead to the discovery of a second necessary activation signal. Finally, the CPX stress response pathway is categorized as a general envelope stress response that is suppressed by the SigmaE pathway, creating a potentially exploitable weakness in the bacteria's defense.</p> / Dissertation

Diss. (sammanfattning) Stockholm : Karol. inst. / Härtill 4 uppsatser.

Thesis (Ph. D.)--University OF MICHIGAN.

Thesis (M.S.)--University of Wisconsin--Madison, 1963. / Typescript. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 14-16).

Thesis (Ph.D.)--Syracuse University, 2008. / "Publication number: AAT 3333591."

Thesis (Ph. D.)--University of Wisconsin--Madison, 1975. / Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references.

Thesis (Ph. D.)--New York University, Graduate School of Arts and Science, 2003. / Typescript. Includes bibliographical references (leaves 121-130). Also available in electronic format on the World Wide Web. Access restricted to users affiliated with the licensed institutions.

DISSERTATION (PH.D.)--THE UNIVERSITY OF MICHIGAN