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A comparison between oestrogen and HER-2 immunohistochemical staining of core and excision biopsy specimens in breast cancerVermaak, Jacobus Stephanus 06 February 2014 (has links)
Immunohistochemical staining for oestrogen and human epidermal growth factor receptor
(HER)-2 is essential in the management of breast cancer patients. Two histological
specimens are usually obtained during a breast cancer patient’s treatment: the core biopsy
and the final excision specimen.
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Submandibular gland tumours: A clinicopathological review at the Chris Hani Baragwanath and Charlotte Maxeke Johannesburg academic hospitalAtiya, Yahya January 2014 (has links)
A Research Report (Neus7009) submitted to the Faculty of
Health Sciences, University of the Witwatersrand, in
partial fulfilment of the requirement for the degree of
Master of Medicine in Otorhinolaryngology (MFOSENTS60)
Johannesburg 2014 / Background: Reports relating to Submandibular gland tumours are sparsely
reported in the literature. There are some reports of different patterns of tumour types
in black/negroid patients, as compared to Caucasian patients1,2,11.
Aim: To provide an audit of the histopathological types and the clinical presentations
of submandibular gland tumours at our two academic hospitals.
Method: An analytical cross sectional study using retrospective clinical data
from in-patient ward registers, patient’s hospital records, operating room/theatre
registers and the NHLS databases. The study was conducted in the ENT units at the
Chris Hani Baragwanath Academic Hospital and the Charlotte Maxeke
Johannesburg Academic Hospital, over a chosen period of 7 years from January
2005 to December 2011.
All patients who had a submandibular gland excision by members of the ENT
department at the two hospitals were included. A total of 61 patient records were
examined, of which 26 met the inclusion criteria. Data collected included age,
gender, race and histological diagnosis.
Data was analysed using standard statistical methods.
Results: Twenty six patients were included in this study, comprising 46%
females and 54% males. The ages ranged from 22 to 65 years, with a mean of 42.5
years – the majority being in the 22-40 years age group. There was no statistical
difference in the age of males and females (p=0.29), nor in black vs. white patients
(p=0.29).
Benign disease was found in 65.4% of patients, while 34.6% had malignancy. Black
patients had a higher ratio of benign disease than white patients, and black males
were more likely to have benign disease (83.33%) than black females (50%).
However, there was no statistical difference in the ratio of benign to malignant
tumours between blacks and whites.
Histopathologically, pleomorphic adenoma was the most common benign tumour
(82%), while adenoid cystic carcinoma was the most common epithelial malignancy
(22%). There was a high incidence of lymphoma (56% of patients) in the malignant
group.
Local pain (p=0.03) and peripheral neurological deficit (p=0.05) was found to be
significantly associated with malignancy.
Conclusion: The rate of malignancy in Black patients was found to be lower
than that reported in the Western literature, which is in keeping with other studies in
non-Caucasian (Black, Asian and Hispanic) populations1,2,9,11. Additionally, Black
patients presented at a younger age. Pain and local/peripheral neurological
involvement were clinical indicators of malignant disease.
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A retrospective study comparing expandable metal stenting with radiation therapy in advanced oesophageal carcinoma in a regional South African hospitalLiakos, Dimitri January 2012 (has links)
A research report submitted to the Faculty of Medicine, University of the
Witwatersrand, in partial fulfillment of the requirements for the Degree of
Master of Medicine in the division of General Surgery.
Johannesburg 2012 / Oesophageal cancer causes much morbidity and mortality in South Africa.
This disease has a 5-year survival of less than 10% despite improvements in
therapy. Most patients present with advanced disease and are suitable only for
palliative care. Current standard of palliative care for patients with end-stage
oesophageal cancer that present with dysphagia include brachytherapy and
stenting. Brachytherapy improves survival and has a more stable quality of life
in the long term when compared to stenting. Conversely stenting has a more
acute relief of dysphagia. In South Africa many patients with malignant
dysphagia face socio-economic constraints that cause delays in therapy,
especially in patients from rural areas.
Many prospective randomized trials of palliative treatment have been done in
the developed world, not taking into account socio-economic constraints. We
present a study from Tshepong Hospital (Klerksdorp, North West province), a
secondary hospital in South Africa.
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Novel cancer therapeutics, the generation of ROS, and cell survival /Mitchell, Clint, January 2006 (has links)
Thesis (Ph. D.)--Virginia Commonwealth University, 2006. / Prepared for: Dept. of Biomedical Engineering. Bibliography: leaves 202-220. Also available online.
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Über das Carcinom des äusseren OhresLangguth, Hugo. January 1896 (has links)
Thèse : Médecine : Strasbourg : 1896. / Numéro d'ordre : 22.
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Therapeutic drugs in cancer and resistanceMartin, Aditi Pandya. January 1900 (has links)
Thesis (Ph.D)--Virginia Commonwealth University, 2009. / Prepared for: Dept. of Pharmacology and Toxicology. Title from title-page of electronic thesis. Bibliography: leaves 134-160.
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Chemical aspects of mitochondrial targeting in photodynamic therapy /Bartlett, Jeremy A. January 2002 (has links)
Thesis (Ph. D.)--University of Wisconsin--Madison, 2000. / Includes bibliographical references (leaves 213-223). Also available on Internet.
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Optimization of pretargeted radioimmunotherapy /Hamblett, Kevin James, January 2002 (has links)
Thesis (Ph. D.)--University of Washington, 2002. / Vita. Includes bibliographical references (leaves 113-126).
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Smoking during first pregnancy and the risk of breast cancer /De Roo, Lisa Anne. January 2004 (has links)
Thesis (Ph. D.)--University of Washington, 2004. / Vita. Includes bibliographical references (leaves 35-43).
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Risk of breast cancer and induced abortion /Ye, Zhan. January 2000 (has links)
Thesis (Ph. D.)--University of Washington, 2000. / Vita. Includes bibliographical references (leaves 92-100).
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