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The Global ETD Search service is a free service for researchers
to find electronic theses and dissertations. This service is
provided by the
Networked Digital Library of Theses and Dissertations.
Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
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Showing 151 to 160 of 7106 (0.058 seconds)Spelling suggestions: "subject:". amolecular biology"" "subject:". 7molecular biology""
| 151 |
Cryptochromes regulate IGF-1 production and signaling through control of JAK2-dependent STAT5B phosphorylationCHAUDHARI, AMOL SANTOSH 18 July 2017 (has links)
No description available.
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| 152 |
Proposed Roles for Sox Transcription Factors and Growth Factor Receptors in NF1Sites, Emily January 2008 (has links)
No description available.
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| 153 |
Regulation of Vascular Patterning by Macrophages and MicrogliaStefater III, James January 2011 (has links)
No description available.
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| 154 |
Study of MicroRNA-34a mediated post transcriptional regulation of MDM4Mandke, Pooja P. 18 September 2012 (has links)
No description available.
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| 155 |
<i>Zebrafish Hdac1</i> Is Reiteratively And Differentially Required During Neural Crest Cell Development And <i>Hdac1</i> Is A Positive Regulator Of The Non Canonical Wnt Signaling PathwayIgnatius, Myron Steve 05 September 2008 (has links)
No description available.
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| 156 |
Molecular Mechanisms of NF-kB Regulation of Skeletal MyogenesisBakkar, Nadine 21 October 2008 (has links)
No description available.
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| 157 |
Zebrafish Neuronal Nicotinic Acetylcholine Receptors: Cloning, Expression, and Functional AnalysisAckerman, Kristin M. 12 February 2009 (has links)
No description available.
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| 158 |
Examining Post-transcriptional Regulation of the Notch Pathway during Vertebrate DevelopmentRiley, Maurisa Flynn 26 September 2011 (has links)
No description available.
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| 159 |
The Role of MicroRNA-181a in Acute Leukemia: Biological, Clinical, and Therapeutic ImplicationsHickey, Christopher Jon 16 December 2011 (has links)
No description available.
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| 160 |
MECHANISMS OF G PROTEIN-COUPLED RECEPTOR 2 REGULATION AND INHIBITION IN CARDIOVASCULAR DISEASE AND AGINGLieu, Melissa January 2020 (has links)
G protein-coupled receptor kinase 2 (GRK2) has been a thriving therapeutic target for cardiovascular disease treatment since its discovery for desensitizing and downregulating b-adrenergic receptors that are vital to cardiac function. GRK2 inhibition through a variety of methods in animal models of cardiac ischemia and heart failure achieved improvements in cardiac function, hemodynamic function, cardiomyocyte apoptosis, and fibrotic scar size among many other observations. Although GRK2 has been used as a therapeutic tool in multiple studies, its mechanisms of regulation are necessary to understand its role in disease pathogenesis and therapeutic application. This dissertation comprises two projects (1) investigating the microRNA (miRNA) regulation of GRK2 and (2) investigating the impact of loss of dynamic regulation of GRK2 through S-nitrosylation. (1) Candidate miRNAs were selected from miRNA microarray analysis of miRNA differential expression data and bioinformatic prediction. In vitro validation of kshv-miR- K12-3-5p and hsa-miR-181a-5p have shown their ability to bind to the GRK2 3’UTR as well as significantly decrease GRK2 mRNA or protein. The successful regulation of GRK2 through these miRNAs warrant in vivo application and investigation as GRK2-targeting HF therapy in a mouse model of HF. (2) In order to determine the impact of chronic GRK2 overactivity, mice that contained a knock-in mutation of GRK2 Cys340àSer (GRK2- C340S), a site of dynamic inhibitory regulation by S-nitrosylation, were allowed to age >12 months. Loss of S-nitrosylation of GRK2 was sufficient to cause cardiovascular remodeling and dysfunction over time. / Biomedical Sciences
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