In this Thesis we explore, both theoretically and numerically, splitting strategies for a hyperbolic system of one-dimensional (1D) blood flow equations with a passive scalar transport equation. Our analysis involves a two-step framework that includes splitting at the level of partial differential equations (PDEs) and numerical methods for discretizing the ensuing problems. This study is inspired by the original flux splitting approach of Toro and Vázquez-Cendón (2012) originally developed for the conservative Euler equations of compressible gas dynamics. In this approach the flux vector in the conservative case, and the system matrix in the non-conservative one, are split into advection and pressure terms: in this way, two systems of partial differential equations are obtained, the advection system and the pressure system. From the mathematical as well as numerical point of view, a basic problem to be solved is the special Cauchy problem called the Riemann problem. This latter provides an analytical solution to evaluate the performance of the numerical methods and, in our approach, it is of primary importance to build the presented numerical schemes. In the first part of the Thesis a detailed theoretical analysis is presented, involving the exact solution of the Riemann problem for the 1D blood flow equations, depicted for a general constant momentum correction coefficient and a tube law that allows to describe both arteries and veins with continuous or discontinuous mechanical and geometrical properties and an advection equation for a passive scalar transport. In literature, this topic has been already studied only for a momentum correction coefficient equal to one, that is related to the prescribed velocity profile and in this case corresponds to a flat one, i.e. an inviscid fluid. In the case of discontinuous properties, only the subsonic regime is considered. In addition we propose a procedure to compute the obtained exact solution and finally we validate it numerically, by comparing exact solutions to those obtained with well-known, numerical schemes on a carefully designed set of test problems. Furthermore, an analogous theoretical analysis and resolution algorithm are presented for the advection system and the pressure system arising from the splitting at the level of PDEs of the complete system of 1D blood flow equations. It is worth noting that the pressure system, in case of veins, presents a loss of genuine non-linearity resulting in the formation of rarefactions, shocks and compound waves, these latter being a composition of rarefactions and shocks. In the second part of the Thesis we present novel finite volume-type, flux splitting-based, numerical schemes for the conservative 1D blood flow equations and splitting-based numerical schemes for the non-conservative 1D blood flow equations that incorporate an advection equation for a passive scalar transport, considering tube laws that allow to model blood flow in arteries and veins and take into account a general constant momentum correction coefficient. A detailed efficiency analysis is performed in order to showcase the advantages of the proposed methodologies in comparison to standard approaches.