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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.

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Showing 1 to 2 of 2 (0.027 seconds)

Spelling suggestions: "subject:"2chloropyrimidine"" "subject:"2dichloropyrimidine""

1

Synthesis of 2,4-Disubstituted Pyrimidines of Possible Biological Interest

Barnes, Samuel 02 May 2008 (has links)
The synthesis of 2,4-disubstituted pyrimidine derivatives is described. The synthetic route involved the addition reaction of lithiated intermediates, mostly heterocycles, to position 4 of 2-chloropyrimidine to give a dihydropyrimidine intermediate which was oxidized back to a pyrimidine. This was followed by nucleophilic aromatic substitution with various amines of the chlorine in the position 2. A number of compounds were prepared which showed binding towards various serotonin receptors in preliminary biological evaluation.
2-chloropyrimidine
lithium
lithiated
heterocycle
heterocyclic
serotonin
pyrimidine
synthetic
synthesis
Organic
organic chemistry
2

Synthesis of 2,4-Disubstituted Pyrimidine Derivatives as Potential 5-HT7 Receptor Antagonist.

Sullivan, Shannon M. 05 May 2008 (has links)
The synthesis of a series of 2-chloropyrimidine derivatives is described. The synthesis began with a nucleophilic addition of lithiated heterocyclic molecules to the 4 position of 2-chloropyrimidine to give dihydropyrimidine intermediates. The intermediates were oxidized to the pyrimidine ring using the DDQ method. This was followed by an addition-elimination reaction of an amine to the 2-chloropyrimidine derivative. The structure and properties of the final compounds were analyzed by melting point, combustion analysis, and 13C-NMR and 1H-NMR spectroscopy. Biological activities in vitro of the synthesized compounds as antagonists of the 5-HT2a and 5-HT7 receptors were determined by an independent laboratory.
Lithiated heterocyclic organic molecules
5-HT2a
5-HT7 receptor
2-4-Disubstituted pyrimidines
2-Chloropyrimidine
Nucleophilic addition reaction
Dihydropyrimidine
Addition-Elimination reaction
Heteroaryl
Pyrimidine

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