The concept of transient electronics emerged to minimize E-waste. Ideal transient electronics operate equivalent to conventional electronics, and the entire device disintegrates after a stable operation period. The discovery of graphene opened a new realm of two-dimensional(2D) material science. 2D materials appealed to the attention of the scientific community on account of their combinations of electronic, optical, robust mechanical, and chemical properties that are characteristically distinct from their parental 3D materials. Furthermore, the diverse inclusion of different electronic/optical properties of 2D material makes them advantageous entrants towards novel electronics/ optoelectronics applications. Near atomic thick two-dimensional (2D) molybdenum disulfide (MoS2) terminated with sulfide anions poises minimal toxicity. However, 2D TMDs integrated optoelectronic transient devices and their intrinsic transient characteristics are not extensively explored. A green approach, such as water-assisted integration of 2D MoS2, only requires water and paves the way for integrating 2D MoS2 into any arbitrary substrate, i.e., biodegradable cellulose and Ca-alginate for potential transient electronics. Our studies outlined the feasibility of integrating 2D MoS2 and biodegradable and biocompatible metals/substrates in transient electronics. We drafted a water-assisted green integration of 2D MoS2 on biodegradable cellulose and curved/ tubular natural rubber substrate. We also edged the integration of calcium alginate on 2D MoS2 as an active device component. We demonstrated proof-of-concept 2D MoS2 integrated transient electronics, i.e., pressure sensor, photodetector, biodegradable electrolyte gated 2D MoS2 field effect transistor (FET). In this study, we outlined the dissolution characteristics of 2D MoS2 using food ingredient baking soda buffer solution; furthermore, we studied a novel approach of ultraviolet, UV-triggered degradation of 2D MoS2 on calcium alginate incorporated with riboflavin polymer matrix. Overall, our study sketched the likelihood of integrating 2D MoS2 towards transient electronic devices, and transient characteristics of 2D MoS2 enabled on biodegradable polymers.