Class of 2016 Abstract and Report / Objectives: An estimated 5.7 million Americans had heart failure (HF) in 2012 with an economic cost of $30.7 billion. By 2030 the prevalence of the disease is expected to increase by 46%. Centers for Medicare and Medicaid Services penalizes hospitals for 30-day readmissions. This study evaluated the effect of our multidisciplinary HF intervention on readmissions. Methods: This is a retrospective cohort study. Patients were identified from electronic inpatient admission records from January 1 to December 31, 2014. Patients who received any component of intervention were compared to patients who did not receive any intervention. Intervention included student pharmacist medication counselling, HF education, and post-discharge phone calls with Modified Morisky questionnaire. Age, sex, admission/discharge dates, readmission diagnosis, smoking status, ejection fraction, medications, and Charlson Comorbidity Index (CCI) conditions were collected. Results: A total of 221 patients with 249 discrete admissions were identified. No difference in age (p=0.42), sex (p=0.48), smoking status (p=0.10) existed between the groups. No difference in readmissions was found between patients receiving complete intervention and control (p=0.41) or patients receiving 1 or 2 intervention components and control (p=0.41). Patients with CCI score≥ 8 had greater risk of readmission compared to CCI scores 0-2 (OR 7.7, 95% CI 1.6-36.3, p=0.01). Conclusions: This analysis did not identify an intervention impact on 30-day readmissions in patients with HF; high CCI scores were associated with increased readmission risk. The intervention may be best targeted towards patients with high CCI scores as they have the highest readmission rate.