This thesis seeks to examine the interrelationships between gender, migration and rural livelihoods in Ghana. The central argument of the study is that policy making on migration and livelihood, tends to ignore gender as a critical issue in development planning. The study suggests that effective development policy interventions should take into consideration the dynamics of gender relations because men and women experience migration differently. Employing primary and secondary data, the study demonstrates that when men and/or women migrate, there are consequences for households. For those migrating, this can result in either empowerment or increased vulnerability. And for the agricultural households in the sending areas, the departure of men and/or women affects their livelihood and division of labour. Our investigation shows that migrants are predominantly males, with a relatively smaller but increasing number of women. Drawing on earlier studies, the thesis argues for a more systematic examination of the consequences of migration on rural households, particularly on the economic livelihood and household responsibilities of women. By understanding the conditions of rural households, development practitioners are in a better position to design gender appropriate policies and projects. This approach will significantly improve the economic situation of rural communities and maximize their development dividends. The study has practical significance as it sheds light on the options faced by rural women, and the adjustments they make, when confronted with male out-migration.