A study of cleft lip and cleft palate was carried out in order to determine whether or not any differences in incidence between Europeans and Polynesians were accompanied by differences in recurrence risks, and to test the genetic hypotheses currently favoured as explanations of familial agggregation of these disorders. An incidence study vas undertaken on all live births in the Auckland urban area for the years 1960 to 1976.Family information was obtained from these probands and from other affected persons or their close relatives, by interview at the cleft palate clinic at Middlemore Hospital. The ascertainment probability for cleft 1ip and cleft palate probands was about 95% and was not correlated with any of the demographic characteristics measured on the probands. After correction for ascertainment, the incidence of cleft palate in Maoris was estimated to be 1.867/1000 1lve births. For Europeans the estimate was 0.643/1000. The corresponding figures for cleft lip with or without cleft palate were 0.397/1000 and 1.195/1000. The sex ratio for cleft palate was 0.485 with heterogeneity between the races. For cleft lip the sax ratio was 0.649 overall. There were no secular or seasonal trends in the incidence of facial clefts and no significant effects of maternal age, or paternal age. The mean birth rank for probands with cleft lip with or without cleft palate was higher than expected. For probands with cleft palate, mean birth rank was not significantly elevated. The pattern of additional malformations in these probands was similar to those reported in similar studies from other centres. The recurrence risk for cleft palate was 1.8% overall. Although it was s1ightly higher in polynesian families than in European families, the difference was nowhere near statistical significance. For cleft lip the recurrence risk was 2.6% overall, with the risk being slightly higher in Polynesian families, but again not significantly higher than in European families. Using current analytical techniques, no discrimination was possible between a generalized single autosomal locus model and a multifactoriar threshold model. A consideration of the parameter estimates for both models suggests that the multifactorial threshold model is the more appropriate one to use for the calculation of recurrence risks in complicated family situations. It is concluded that further family studies of this nature would no longer be warranted unless hypotheses can realistically be tested on the samples available. However, incidence studies in special populations will remain important for hypothesis testing. Following on the work using animal models, a study of face shape within and among races in New Zealand may provide clues to the aetiology of facial clefts, particularly isoleted cleft palate. It will be important to follow changes in incidence over time and discover what effects intermarriage and cultural changes might have on the incidence of facial clefts.

Whole document restricted, see Access Instructions file below for details of how to access the print copy. / Background: Giardia is a leading cause of human gastrointestinal illnesses globally and is the most commonly notified waterborne disease in New Zealand. The national incidence rate of 46.6 per 100,000 is thought to be one of the highest among developed countries, peaking in the 1-4 and the 25-44 age groups. Risk factors for infection among vulnerable groups have not been explored systematically in New Zealand, although environmental factors and person-to-person transmission have been suspected. The true burden of Giardia infecion in the community has been difficult to estimate due to suspected under-notification of the disease. An important component of disease surveillance and the validation of disease incidence rates is an estimation of the degree of undercount. AIMS: To describe the epidemiological patterns of Giardia infection in the Auckland region and in New Zealand, compare them with local and international patterns of infection, and explore environmental links. To estimate the level of completeness of giardiasis notification in the Auckland adult population by using a simple capture-recapture method. To identify risk factors for giardiasis among Auckland children under 5 years of age. Methods: Analysis of Auckland data: Anonymised giardiasis notification data from Auckland Regional Public Health Services (ARPHS) for the period of July 1996 to June 2000 were analysed by person, place and time. Infection rates and relative risks were calculated and compared with national and international information. Analysis of New Zealand data: A study of national surveillance data utilised anonymised information for 7818 notified cases throughout New Zealand between July 1996 and June 2000. A weighted average of drinking water grades was estimated using the Community Drinking Register. Pearson's coefficient was used to measure the correlation between average drinking water grades and notified cases. Daily climate data were plotted against daily case notifications and modelled, using Poisson's regression, to predict any influence of climate on infection. Data were presented by age, gender, ethnicity and area using statistical and spatial methods. Estimation of under-notification: The capture-recapture technique is now being used in many countries to evaluate the completeness of disease ascertainment. Comparison of disease ascertainment involves two or more datasets. Two independent datasets of giardiasis cases aged 15 years or over were generated. Of them one was generated from the demographic information of cases recruited during the Auckland Giardiasis Study in 1998-99 and the other from giardiasis cases notified to the ARPHS for the same period of time. The area of residence of cases was geo-coded, mapped and overlaid by water distribution zones. Cases were matched and under-notification was estimated using a two-sample capture-recapture method. Case-control study: A case-control methodology was used to analyse the exposure history of 69 cases and 98 controls under 5 years of age in Auckland. Significant risks of infection were estimated and their attributable risks. Results: Giardiasis in Auckland: Auckland had a significantly higher rate of Giardia notification (58/100,000) than New Zealand (46/100,000) as a whole. Notification rates, which peaked during February-May, were significantly higher in Pakeha/Europeans and Asian/others, compared with Maori/Pacificans. Adjusted notification rates were higher for residents of North Shore and Auckland cities than for other areas of Auckland. The crude regional and national notification rates were almost 6 times the rate of laboratory identification of positive isolates in the UK and 4 times US reported rates. Giardiasis in New Zealand: At the national level, most cases occurred in the 1-4 year age group followed by the 25-44 year age group, and most cases were Pakeha/European. Ethnicity was not known for 18% of cases, affecting demographic calculations. Infection rates were high for a number of Health Districts (West Coast, Wanganui, Waikato and Tauranga) compared to the national average. Over 50% of the population received Aa-graded drinking water. No correlation between infection and the weighted average grades for water treatment plants (r = -0.12) or the reticulation systems (r = -0.11)) was found. A significant correlation with the mean daily maximum (r = 0.05) and minimum (r = 0.06) temperature was observed. Poisson's regression modelled minimum-temperature (chi2 = 5.40, p<0.05) and relative humidity (chi2 = 5.37, p<0.05) as predictors of a significant number of Giardia infections on a given day. Under-notification of giardiasis: The estimation of under-notification during the 12 month period, compared 413 cases who were notified to the ARPHS with 199 cases who had participated in a case-control study over the same period of time. North Auckland had slightly higher notification rates and also study participation rates. The giardiasis notification rate was higher in un-reticulated water zones (72.4/100,000 population). The capture-recapture calculation indicated that only 49% of cases were notified. Risk of giardiasis in children: In the case-control study, 95% of cases and 86% of controls used water from the Auckland Metropolitan Mains (AMM) supply for domestic purposes, 44 cases and 42 controls swam, and 59 cases and 54 controls wore nappies. Children wearing nappies were at significantly increased risk of the disease (OR=3.0, 95%CI 1.01-8.9), as were those from households which had more than one child wearing a nappy (OR=6.5, 1.8-23.4). The AMM water supply was associated with a reduced giardiasis risk compared to other drinking water sources. Significantly increased risks were associated with drinking water consumed away from home (OR=4.7, 2.2-10.1), swimming at least once a week (OR=2.4, 1.1-5.3) and travelling in side New Zealand (OR=2.5, 1.03-6.0). Conclusions: The higher rates of giardiasis observed in Auckland and New Zealand, in comparison with other developed countries, may be related to environmental or social factors. Missing ethnicity information precludes clear interpretation of variations in notification rate by ethnic group and suggests a need for improvement in data collection. There are opportunities to investigate the influence of risk factors on seasonal changes in notification rates both locally and nationally. Reported improvements in some areas could be due to local health measures or to random variation. Time-trend analysis suggests a seasonal pattern. The weighted average drinking water grading is a novel and readily available measure, and may not be truly representative of local supplies. Modelling of climate data showed an association with giardiasis but was inconclusive. Giardia notifications in Auckland are under-notified by half. This has obscured the true burden of Giardia infection. This has implications for estimates of the burden of disease in New Zealand. Notification rates vary inversely with socio-economic conditions and the presence of a reticulated water system. The case-control study identified vulnerable groups and modifiable risk factors for Giardia infection. Nappy-wearing was an independent risk factor for infection. Further study is advocated to ensure better protection of public health, especially for children. These studies identified vulnerable groups and major data-gaps. The risk of infection in children needs further attention for effective infection control measures to be developed for this disease. Recommendations for improvements in disease surveillance and data quality are discussed. GIS (Geographical Information System) is a useful tool for disease monitoring. Capture-recapture techniques are useful tools in evaluating the completeness of disease surveillance.

Background Road traffic injury is projected to rank as the third largest contributor to the global burden of disease by 2020. Disability is a significant component of the burden of disease ranking. Most published data on traffic crash outcomes, however, focus primarily on deaths and hospitalisations. Reliable estimates of post-crash disability and information on factors that modify the disabling process are essential to prioritise and allocate appropriate resources for road traffic injury prevention and interventions that reduce the risk of secondary disability. Aims To quantify the risk of disability associated with serious injury crashes in car drivers in a defined population; to explore the extent to which this risk is modified by chronic alcohol abuse; and to critically review methodological approaches that can redress the inadequate epidemiological attention to injury-related disability. Methods Systematic reviews were conducted to examine the available epidemiological evidence quantifying the association of car crashes with disability and the effect of alcohol on the risk of post-injury disability. Studies published or presented between January 1980 and April 2003 were reviewed. No language restriction was imposed. A population-based prospective cohort study conducted in the Auckland region of New Zealand recruited drivers exposed to serious injury crashes (identified through a surveillance system monitoring hospital admissions of injured car occupants). A representative sample of car drivers in the region was identified through roadside surveys (controls). The participants were interviewed at recruitment (to obtain pre-crash information from crash drivers and baseline data from controls) and re-interviewed at five and eighteen-months follow-up. Structured interviews on all three occasions included the Short Form-36, a global health change indicator, and the Alcohol Use Disorders Identification Test. Information on a range of potential confounders was sought at baseline through the interview, alcohol measurements and clinical records. Results Studies identified in the systematic reviews revealed that published estimates of the risk of post-crash disability ranged from 2% to 57%. The evidence regarding the effect of alcohol on post-injury disability is inconclusive largely because none examined this association directly. Most studies identified in the reviews were limited by several methodological problems including the absence of appropriate comparison groups, inadequate or no adjustment for confounding, significant potential for selection bias due to the study setting, high levels of loss to follow-up, and missing data. In the prospective cohort study, 215 crash drivers (75% follow-up) and 254 controls (69%) completed the 18-month interview. Overall, 40% of the drivers who were hospitalised, 20% of the crash drivers not hospitalised, and 7% of the controls reported deteriorated health at 18 months relative to their baseline health. This represents a tenfold excess risk of disability among hospitalised drivers and a three-fold excess risk among non-hospitalised crash drivers, relative to drivers in the general population. Among crash drivers reporting an overall decline in health, clinically important reductions in general and mental health were apparent over the follow-up period despite improving physical health and function. This trend was more evident among non-hospitalised than hospitalised crash drivers. Compared with drivers who were neither involved in a crash nor defined as hazardous drinkers, crash drivers who were hazardous drinkers had a seven-fold excess risk of a clinically significant (≥ 10%) decline in the SF-36 general health score (OR 6.85; 95% CI: 1.84-25.43). Crash drivers who were not hazardous drinkers had a three-fold risk (OR: 3.00; 95% CI: 1.14-7.89). The results indicated an important interaction between crash involvement and chronic alcohol abuse in potentiating the risk of disability. Conclusion Serious traffic crashes are associated with significant longer-term disability in a substantial proportion of survivors with an apparent worsening of mental health over time. Definitions of disability and estimates of the burden of disability following traffic injury remain highly variable in the published literature and it is timely for the international research community to develop a more systematic and consistent approach to this major and increasing component of the global burden of disease. By addressing the main methodological limitations of previous studies, this study revealed that chronic alcohol abuse potentiates the risk of post-crash disability. The findings suggest that measures for preventing road traffic crashes as well as efforts to identify problem drinkers among crash survivors should be intensified. The thesis highlights the need for robust indicators of non-fatal injury to monitor the impact of road safety programs and large-scale epidemiological studies to investigate the spectrum and determinants of post-injury disability.

The primary aim of the study was to validate the short and long form of the recently-created NZ physical activity questionnaires (NZPAQ-SF and NZPAQ-LF, respectively) in a multi-ethnic sample in Auckland. An international physical activity questionnaire (IPAQ-long) was also validated and compared to the NZ instruments. Objective PA measures were used to create a NZ compendium of PA intensities, providing baseline data for culturally-specific PAs. Secondary aims included an examination of the relationship between PA and CRF, and their associations with cross-sectional measures of cardiovascular (CV) risk factors. The study sample consisted of 186 apparently healthy males (n=90) and females (n=96) aged 19-86 yrs, classified as European/Other (n=60), Māori (n=61), and Pacific (n=65). Heart rate monitoring (HRM) with individual calibration was used to objectively measure the duration, frequency, and intensity of at least moderate-intensity PAs performed over 3 consecutive days. Type of PA and the context in which it was performed was simultaneously recorded by participants on daily PA logs. Correlations between HRM and self-reported levels of brisk walking, moderate-intensity, vigorousintensity, were poor for each questionnaire, and correlations were lower for Māori and Pacific ethnic groups than for European/Other. The NZPAQ-SF (r=0.3, p<0.001) and NZPAQ-LF (r=0.3, p<0.001) performed better than the IPAQ-long (r=0.1, p=0.37). The culturally-specific list of PA intensities showed strong correlation (R2=0.68) to an internationally-accepted compendium of PA intensities, and provided baseline energy cost data for 13 PAs performed by Māori and Pacific people in NZ. CRF levels were primarily influenced by gender, ethnicity, obesity, and performing at least 15 min/day of vigorous-intensity PA, and showed stronger associations with fasting blood lipids and glucose, while PA was more strongly related to SBP and DBP. The validated NZPAQs are acceptable for measuring population level PA prevalence in NZ adults, although accuracy is lower for Māori and Pacific people. However, the availability of a culturallyspecific list of PA intensities could potentially increase the accuracy of self-reported PA by Māori and Pacific people. Results from this study highlight the importance of vigorous-intensity PA for CV health, and identifies NZ Pacific people as high risk in terms of PA, obesity, and CRF.

The risk of developing type 2 diabetes is four fold higher in New Zealand(NZ) Polynesians compared to Caucasians. Hence diabetes is more prevalent in Maori (16.5% of the general population) and Pacific Island people (10.1%) compared to NZ Caucasians (9.3%). It is generally accepted that type 2 diabetes has major genetic determinants and heterozygous mutations in a number of genes have previously been identified in some subsets of type 2 diabetes and certain ethnic groups. The high prevalence of diabetes in NZ Polynesians, when compared with NZ Caucasians, after controlling for age, income and body mass index (BMI), suggest that genes may be important in this population. Therefore, the prevalence of allelic variations in the genes encoding amylin and insulin promoter factor-1 (IPF-1), and exon 2 of the hepatocyte nuclear factor-1α (HNF-1α) gene in NZ Polynesians with type 2 diabetes was determined. These genes are known to produce type 2 diabetes in other populations. The genes investigated were screened for mutations by PCR amplification and direct sequencing of promoter regions, exons and adjacent intronic sequences from genomic DNA. DNA was obtained from 146 NZ Polynesians (131 Maori and 15 Pacific Island) with type 2 diabetes and 387 NZ Polynesian non-diabetic control subjects (258 Maori and 129 Pacific Island). Sequences were compared to previously published sequences in the National Centre for Biotechnology Information database. Allelic variations in IPF-1 and exon 2 of the HNF-1α gene were not associated with type 2 diabetes in NZ Polynesians. However, in the amylin gene, two new and one previously described allele was identified in the Maori population including: two alleles in the promoter region (-132G>A and -215T>G), and a missense mutation in exon 3 (QlOR). The -215T>G allele was observed in 5.4% and l% of type 2 diabetic and non-diabetic Maori respectively, and predisposed the carrier to diabetes with a relative risk of 7.23. The -215T>G allele was inherited with a previously described amylin promoter polymorphism(-230A>C) in 3% of Maori with type 2 diabetes, which suggests linkage equilibrium exists between these two alleles. Both Q10R and -132G>A were observed in 0.76% of type 2 diabetic patients and were absent in non-diabetic subjects. Together these allelic variations may account for approximately 7% of type 2 diabetes in Maori. These results suggest that the amylin gene maybe an important candidate marker gene for type 2 diabetes in Maori.

This social-cultural history explores the changing context, culture, and identity of psychiatric nurses working in New Zealand public mental hospitals between 1939 and 1972. Primary documentary sources and oral history interviews provided the data for analysis. The thesis is divided into two periods: 1939 to 1959 when asylum-type conditions shaped the culture of the institutional workforce, and 1960 to 1972 when mental health reform and nursing professionalisation challenged the isolation and distinct identity of mental hospital nurses. Between 1939 and 1959 the introduction of somatic treatments did not substantially change nursing practice in mental hospitals. Overcrowding, understaffing and poor resources necessitated the continuance of custodial care. The asylum-type institutions were dependent on a male attendant workforce to ensure the safety of disturbed male patients, and the maintenance of hospital farms, gardens, and buildings. Although female nurses provided all the care and domestic work on the female side, the belief that psychiatric nursing was physically demanding, potentially dangerous, and morally questionable, characterised the work as generally unsuitable for women. Introduction of psychiatric nursing registration which was a move toward professionalisation did little to change the dominance of a male, working-class culture. From 1960 to 1972 psychiatric nurses’ identity was contested. New therapeutic roles created the possibility of the nurses becoming health professionals. Their economic security and occupational power, however, was tied to an identity as unionised, male workers. As psychiatric nurses were drawn closer to the female-dominated nursing profession through health service changes and nursing education reform, both men and women acted to protect both their working conditions and their patients’ welfare. To achieve these ends, they employed working-class means of industrial action. By accepting the notion that psychiatric nurses’ identity was socially constructed, this thesis provides an interpretation that goes beyond the assumption that nursing is a woman’s profession. Instead, it presents psychiatric nursing as a changing phenomenon shaped by contested discourses of gender, class and professionalisation. Nursing in public mental hospitals attracted ordinary men and uncommon women whose collective identity was forged from the experience of working in a stigmatised role.

This research began a journey towards improved maturity around data quality management in New Zealand health care, where total data quality management is 'business as usual" institutionalised into the daily practices of all those who work in health care. The increasingly information intensive nature of health care demands a proactive and strategic approach to data quality to ensure the right information is available to the right person at the right time in the right format, all in consideration of the rights of the patient to have his/her health data protected and used in an ethical way. The work extends and tests principles to establish good practice and overcome practical barriers. This thesis explores the issues that define and control data quality in the national health data collections and the mechanisms and frameworks that can be developed to achieve and sustain good data quality. The research is interpretive, studying meaning within a social setting. The research provides the structure for learning and potential change through the utilisation of action research. Grounded theory provides the structure for the analysis of qualitative data through inductive coding and constant comparison in the analysis phase of the action research iterative cycle. Participatory observation provided considerable rich data as the researcher was a member of staff within the organisation. Data were also collected at workshops, focus groups, structured meetings and interviews. The development of a Data Quality Evaluation Framework and a national Data quality Improvement Strategy provides clear direction for a holistic and 'whole of health sector' way of viewing data quality, with the ability for organisations to develop and implement local innovations through locally developed strategies and data quality improvement programmes. The researcher utilised the theory of appreciative enquiry (Fry, 2002) to positively encourage change, and to encourage the utilisation of existing organisational knowledge. Simple rules, such as the TDQM process and the data quality dimensions guided the change, leaving room for innovation. The theory of 'complex systems of adjustment' (Champagne, 2002; Stacey, 1993) can be instilled in the organisation to encourage change through the constant interaction of people throughout the organisation.

This research was undertaken approximately 20 months after the introduction of alcohol brand advertising on New Zealand television, which resulted in a fourfold increase in televised alcohol advertising and a 42% increase in overall alcohol advertising. The primary aim of the research was to examine the nature of the relationships between young people's responses to televised alcohol advertising and drinking-related behaviours. The research was based on two surveys, one with l0 to 17 year olds and one with 18 to 29 year olds. The l0 to 17 survey involved 500 randomly selected face-to-face interviews in New Zealand's three largest urban areas. The 18 to 29 survey involved 1012 interviews. Respondents were randomly selected from throughout New Zealand and interviewed using a computer-assisted telephone interviewing (CATI) system. Both surveys asked about responses to specific alcohol advertisements, which were ones these age groups had been more exposed to. One of the two key response measures identified how frequently they recalled having seen the advertisement; this was labelled recalled exposure. Positive response to the advertising was measured by liking of the advertisement. Structural equation modelling (SEM) was used for the analyses, but this was preceded by correlation and regression analyses. On the basis of factor analyses that preceded the structural equation modelling, most of the modelling was based on the responses to the three beer advertisements in each study. 10 to 17 year old survey: The findings from the structural equation modelling were consistent with the hypothesis that positive responses to beer advertising (as measured by liking) were contributing to an increase in expected frequency of future drinking. The data were also consistent with the beer advertising contributing to an increased frequency of current drinking, although the relationship was just under the 0.05 level of significance. There was some limited evidence that recalled exposure may be associated with the drinking status of 10 to 13 year olds but, because of the small number of drinkers in this age group, this result needs to be interpreted with caution. The regression analyses indicated that recalled exposure was a predictor of 10 to 17 year olds' perceptions of how often their age/gender group drank and how accepting their friends were of drinking and occasional drunkenness. Other survey responses were also indicative of an influence of alcohol advertising on young people. Alcohol advertising was an important source of information about drinking, particularly for the 10 to 13 year old males. Almost half of these younger males accepted the portrayals in alcohol advertising as realistic and almost two thirds of them felt that alcohol advertising does encourage teenagers to drink. 18 to 29 year old survey: This study provided support for the hypothesis that more positive responses to televised beer advertisements resulted in larger quantities of alcohol being consumed on typical drinking occasions by 18 to 29 year old New Zealanders. It did not provide support for the hypothesis that drinking larger quantities of alcohol led to more positive responses to beer advertisements. The model showed that positive responses to beer advertisements had both a direct influence on quantity and an indirect influence, via its influence on positive beliefs. This study also provided support for the hypothesis that more positive responses to beer advertising were associated with increased alcohol-related problems. As with the 10 to 17 year olds, recalled exposure was related to perceptions of peer influence and behaviour. It was a significant predictor for female perceptions of peer quantities consumed and male and female perceptions relating to peer approval of drunkenness. The regression analyses also identified that recalled exposure was a predictor of males saying they were drinking more than the year before, however a SEM that specified reciprocal paths between these two variables found neither path to be significant. Discussion and implications This research has identified the importance of examining positive responses to alcohol advertisements. This acknowledges the active recipient of advertising who responds positively to advertising that offers valued outcomes. It also emphasises the importance of considering emotional/affective responses to advertising. However, the study also indicates that the weight of advertising is important, as reflected in the cognitive measure of recalled exposure. This appears to be having most influence on perceptions of what is normative behaviour. The results of the SEMs must be viewed as tentative, given the exploratory nature of the analyses and the limitations of cross-sectional surveys. However, as for all the previous studies, relationships have been identified between measures relating to alcohol advertising and those relating to alcohol consumption. While it is not possible to make definitive statements about directions of influence between these variables, these studies have all provided data that are consistent with the theory-based hypothesis that alcohol advertising does have an influence on alcohol consumption by young people.

Cardiovascular disease is the leading cause of mortality in New Zealand. The most current evidence indicates that the burden of cardiovascular disease is greatest among Maori and Pacific peoples and Pacific peoples have the highest mortality rate for cerebrovascular disease [1]. There is substantial scientific evidence that cardiovascular disease has its origin early in life and that a person's risk of cardiovascular disease is determined by the synergistic effect of all the cardiovascular risk factors over time. The Auckland High School Heart Survey (AHHS) is an epidemiological survey designed to determine the prevalence of risk factors for cardiovascular disease in an adolescent high school population in New Zealand. It takes a 'lifecourse' and primary prevention approach to reducing the incidence of cardiovascular disease. The aims of the study were to determine cardiovascular risk factor levels in, and compare the cardiovascular and diabetes risk factor levels between, Pacific and European students and the main Pacific communities (Samoan, Cook Islands, Tongan, and Niuean). The AHHS was a school-based cross-sectional survey of 2,549 adolescent students, across 10 Auckland High Schools. A cluster sampling technique was used to obtain the target of 1000 Pacific participants, to enable Pacific ethnic-specific analysis. The study specifically aimed to determine ethnic-specific differences in lifestyle, intermediate and outcome variables that have been established as cardiovascular risks. Lifestyle variables included: smoking, alcohol consumption, leisure-time physical activity (LTPA), television exposure and sun exposure. The intermediate variables analysed included: body mass index (BMI), waist to hip ratio (WHR), percentage body fat (PBF) and physical work capacity 170 (PWC170). The outcome variables included: total cholesterol (TC), high density lipoprotein cholesterol (HDLC), ratio of total cholesterol to high density lipoprotein cholesterol (TC:HDLC), low density lipoprotein cholesterol (LDLC), triglycerides (TG), fasting blood glucose (FG), urinary micro albumin (UA), systolic and diastolic blood pressure (SBP & DPB). Demographic variables analysed included: sex, age, ethnic group, school, socio-economic status and growth development and maturation. The AHHS study results showed that demographic variables were strongly associated with both intermediate and outcome variables. The findings showed that there were significant ethnic variations between the four main ethnic groups (Pacific, Maori, Asian and European) in risk factors for cardiovascular disease. Pacific participants had the highest BMI and PBF. Pacific participants had the lowest levels of PWC170. With regard to outcome variables, Pacific adolescents had lower levels of TC, HDLC and LDLC compared to Europeans. However, Pacific participants had higher levels of TC:HDLC, FG, TG and DPB. To a lesser degree, lifestyle variables were also associated with other variables. However, the weaker association was likely due to measurement error. The findings of the AHHS study show that ethnic differences present in the adult population are already established among adolescents [2]. Some significant differences were also found between the Pacific ethnic groups (Samoan, Cook Islands, Tongan and Niuean). Among Pacific participants, Cook Islands participants also had the highest level of adjusted mean PWC170. With regard to outcome variables (lipids, fasting glucose and blood pressure), Tongan participants had lower TC, LDLC and TC:HDLC compared to Samoans. However, Tongan participants had significantly higher levels of TG compared to Samoans. For Pacific participants, Cook Islands participants significantly differed from Samoan in smoking, alcohol consumption and PWC170. Cook Islands participants were more likely to have tried smoking for the first time and at an earlier age. They were also more likely to smoke daily and to smoke higher amounts than the other Pacific ethnic groups. Cook Islands participants were more likely to have tried alcohol and at an earlier age. They were also more likely to be drinking alcohol weekly or more often when compared to Samoans. The AHHS study is one of the first pieces of epidemiological research undertaken in New Zealand that provides evidence that there are significant differences between Pacific ethnic groups for this age group. The AHHS study was also able to identify the determinant that explains ethnic differences in outcome variables. BMI was the most significant variable in determining the ethnic differences in outcome variables (lipids, blood pressure and fasting glucose). The AHHS study results showed that Pacific participants had the highest BMI levels of all the ethnic groups, followed by Maori. Television watching was the one lifestyle risk factor that was positively associated with BMI. The most effective variable in terms of decreasing mean difference in BMI was PWC170. PWC170 was significantly lower in Pacific, Asian, and Maori participants compared with European participants. Pacific participants had the lowest levels of PWC170 compared to all other ethnic groups. The AHHS findings support early interventions and programmes targeted to adolescents to reduce the incidence of cardiovascular disease. The findings which show that there are significant differences between Pacific ethnic groups for this age group, may warrant some specific public health initiatives being targeted directly to Pacific ethnic-specific groups. In addition, interventions and programmes that target reducing BMI and improving physical fitness should have an impact on a number of important cardiovascular risk factor outcome variables in adolescents, including: blood pressure, lipids and fasting glucose.

Background: There is a high rate of mental disorders among general practice attendees that is associated with substantial morbidity, disability and global burden. As a consequence GPs play a pivotal role in ensuring that patients with mental disorders are recognised and optimally treated. While there is little doubt of the role GPs play in managing mental illness in general practice the literature suggests a proportion of patients will go unrecognised or else be inadequately diagnosed and in some instances inadequately treated by their GP. The known problems of under diagnosis of mental disorders has been seen until recently to be a problem of GP knowledge and skill, which has led to the close scrutiny of GP performance in this field. In response to this close scrutiny has been the development of a wide range of physician education programs aimed to improving the clinical performance of GPs. However, more recently it has been acknowledged that reasons for low recognition and inadequate treatment of mental disorders in general practice is not only the GPs lack of skill and knowledge, but instead involves a complex interplay of GP, patient and systemic factors unique to GPs, their patients and the general practice setting. Therefore there is a growing interest in research to not only explore ways to improve the clinical performance of GPs, but to also gain a better understanding of the range of issues that GPs are confronted with when managing mental disorders in general practice. Aim: There were two aims of this research: 1) examine GP attitudes, reported confidence and behaviour pertaining to the detection, diagnosis and management of mental illness in general practice (Study One); and 2) describe the epidemiology of depression in general practice and investigate symptom attribution styles as it relates to depression (Study Two). Methodology: In Study One 800 randomly selected rural and urban GPs in the North Island were invited to complete the Attitudes, Reported Confidence and Behaviour Questionnaire Revised (ARCBQ-R). The ARCBQ-R had been previously piloted and reliability and validity issues addressed and published elsewhere. In Study Two, 15 general practices were randomly selected from a database of Auckland General Practices, of which 35 consecutive general care attendees were recruited from each of the 15 general practices. Consenting patients completed a self report questionnaire on mood and health and a computerised version of the Composite International Diagnostic Interview (CIDI) questionnaire (depression module only). Results: Study One: Four hundred and sixteen (52%) GPs completed the ARCBQ-R. GPs are confronted with a wide range of mental disorders in their day-to-day practice, with a predominance of depression and anxiety. GPs were most confident in detecting, diagnosing and treating depression and were most confident in prescribing antidepressants, particularly SSRIs for depression and anxiety. GP confidence in detection, diagnosis and treatment of mental illness was influenced by a number of GP factors such as: interest in mental health, previous mental health training, gender and exposure to mental disorders in their practice. Systemic and patients factors were also reported to influence the way in which GPs recognise and manage mental disorders in their practice. Only a small proportion of GPs reported to use solely DSM-IV or ICD-10 classifications when making a diagnosis, and the majority relied on informal ways to diagnose mental disorders in their patients, which raises questions about the appropriateness of formal diagnostic classifications in general practice. Training needs for this group of GPs involved both treatment and diagnostic issues pertaining to more complex disorders. GPs believed that shared care of mental disorders is the most effective way to provide optimal care for patients. However a number of issues pertaining to availability and assessibility of secondary mental health services along with structural issues such as cost, time and extended consultations in general practice must be addressed before this model of care can work to its full potential. Study Two: A total of 475 general practice attendees agreed to take part in this study. Approximately 20% of general practice attendees met DSM-IV criteria for major depression in the last 12 months and 12% for major depression with a recency of '1 month to less than 2 weeks'. Just under 5% of the sample met DSM-IV criteria for dysthymia, of which 80% had comorbid major depression. A greater proportion of participants who were divorced or separated, unemployed or looking for work, younger in age, of Maori ethnicity and had a history of mental illness met criteria for DSM-IV major depression. Compared to non-depressed participants, depressed participants in this study reported significantly more missed work or social activity in the last year due to emotional problems. With the aid of two screening questions for depression, GPs in this study accurately identified 75% of depressed general practice attendees. The most common attribution style amongst general practice attendees was a normalising attribution style. Patient attribution styles was not found to influence the level of depression detection by GPs, instead past and current illness profiles influenced GP detection rates of depression. Conclusion: The current research findings report figures and trends consistent with overseas studies, not only demonstrating the high prevalence of mental illness, particularly that of depression present in general practice attendees, but the many issues that shape mental health care in general practice. Inline with Klinkman's 'Competing Demands Model' GPs perform three important functions: 1) to identify mental disorders in the community; 2) directly provide mental health care to patients; and 3) a referral agent to secondary mental health services. Like Klinkman's model, results derived from the two studies suggest GPs attitudes towards mental health will shape the level of involvement across these three functions. Results derived from 'Study One' and 'Study Two' extends on Klinkman's model to incorporate 'shared care' as a potential model for managing more severe complex disorders. However, before such a model of 'shared care' can be implemented it is essential that accessibility and communication channels between primary and secondary sectors are improved, and structural funding arrangements including the appropriate remuneration for GPs time is addressed. In reality not all GPs will be interested in managing mental illness in their practice and therefore will not have the motivation to acquire and maintain a level of knowledge sufficient to work with patients with mental illness, whether it be in the capacity of 'shared care' or solely the responsibility of the GP. However, it is not unreasonable to expect GPs to have the necessary skills and ability to at least detect and diagnose mental illness in their patient population, and if necessary refer patients on to secondary mental health services. Prerequisite training in mental health, training in diagnostic classifications along with considerations around their appropriateness in general practice, a sound knowledge of patient risk factors for mental illnesses and established networks with secondary mental health services is necessary before GPs can successfully fulfill these roles.