MSc (Botany) / Department of Botany / Invasive alien plants (IAPs) are non-native species that have spread beyond the introduction site; become abundant to an extent that they serve as agents of change that also threaten native biological diversity (Garcia-Berthou, 2007). IAPs have medicinal applications for the treatment of various aliments in humans (Jäger et al., 1996). In this study, an ethnomedicinal survey was conducted on medicinal uses of invasive alien plant species in order to identify and investigate the various disease treatment methods employed by Bapedi traditional health practitioners within Capricorn District. Six traditional health practitioners were randomly selected, via the snowball method from each of the five local municipalities namely: Aganang, Blouberg, Lepelle-Nkupi, Molomole and Polokwane. The whole survey included 30 traditional health practitioners. A semi structured questionnaire was administered to document information about the medicinal uses of IAPs from participants. The collected data from the questionnaire was captured in Microsoft Excel 2010 and analyzed using descriptive statistics. The study recorded 22 IAPs belonging to 14 plant families. Records or data collected show invasive alien plants species to have been used for treatment of different alignments amongst Bapedi traditional health practitioners. Plant families with the most recorded species include: Solanaceae and Myrtaceae with 18.2% for both of them. The plant parts most frequently used in descending order were as follows: roots vii (40%), followed by the leaves (39%), fruits (7%), thorns (6%), bark (4%), seeds (2%) and lastly stems (2%). Decoction was recorded as the most dominant method used during medicinal preparations (n = 176) and flu was recorded as the most treated ailment amongst traditional health practitioners (n = 29). Apart from clearing IAPs as part of management strategy by South African government, there are other alternative innovative ways that can be employed to ensure that the number of IAPs introduced does not exceed beyond measure.This could be achieved by encouraging local people to use them as either medicinal sources or by incorporating them into any other local ethnobotanical use. The new innovative ways (such as traditional health practitioners utilizing the IAPs instead of endangered plants or indigenous plants species) can bring in some form of relief to the already declining indigenous species populations. Research scholars from different research institutes and higher education research centres can regard IAPs used medicinally as source of new pharmaceutical leads to create new medications. With such attention turned to alien invasive species, their survival as well as their spread will be kept on check at the same time creating a control measure to their spread with little effort. Further laboratory-based studies are needed to determine efficiency and safety of the IAPs used by traditional health practitioners in this study. / NRF