OBJECTIVES: The objective was to investigate the accuracy, storage stability, and mechanical properties of 3D-printed polymeric dental materials. MATERIALS AND METHODS: Three completely dentate models, two maxillary and one mandibular each with their respective die, and three implant models were designed using dental CAD software (3SHAPE DENTAL SYSTEM). A horseshoe-shaped solid base with a posterior horizontal bar was utilized. The models were printed based on the manufacturer's instructions for four weeks using six printers with the corresponding recommended resin materials: Carbon M2 (DPR10), HeyGears A2D4K (Model HP UV2.0), Stratasys J5 (MED610), Stratasys Origin One (DM200), Envision One (E-Model LightDLP), and Asiga Pro4K (VeriModel) with a standard layer thickness of 50 μm (N=72). The models were scanned after printing using Sirona inEOS X5 scanner, while the implant models were scanned using a CT scanner (GE Phoenix V|tome|x metrology edition). The full arch models were randomly assigned to three groups of storage conditions: cold environment (LT, 4 ± 1°C), hot and dry environment (HT, 50 ± 2°C), and room temperature (RT , 25 ± 2°C, serving as the control). Each group was kept under the designated conditions and scanned at 1, 2, 3, 4, and 8 weeks. The generated STL files were imported into a 3D inspection software for comparison with the original STL files. Four sets of reference points (central fossa of first premolars and central fossae of second molars) were selected to determine six distances of inter-arch segments, from which the inter-arch distance trueness and precision deviation were measured. For the second part of the study, maxillary Lucitone Digital Print denture base (DB) (N=5), maxillary Lucitone IPN 3D Premium anterior and posterior teeth (N=6), and maxillary Keystone Keysplint Soft Clear occlusal splint (N=5) were printed using two printers (Carbon M2, Asiga Max UV) with a standard layer thickness of 50 μm for denture base and teeth, and 100 μm for the occlusal splint. The tolerance threshold was set to 50 μm for Lucitone IPN and 100 μm for Lucitone DB and Keysplint Soft. In-tolerance percentage and deviation RMS were obtained and analyzed with multivariate least square mean linear regression using JMP Pro 17 (SAS, Cary, NC) to identify significant effects (α=0.05). The third part investigated the mechanical properties of Lucitone DB and IPN using 2 printers (Carbon M2, Asiga Max UV) as follows: flexural strength (N=10) using a threepoint bend test, fracture toughness (N=10), creep (N=5), Vickers hardness test (N=15), surface roughness (N=15), while Shore A hardness (N=15) and tensile strength (N=10) were performed for Keysplint Soft Clear. Data were analyzed using one-way and multivariate least square mean linear regression followed by Tukey’s HSD test using JMP Pro 17 (SAS, Cary, NC) to identify significant effects (α=0.05). RESULTS: The in-tolerance percentage varied significantly among printers, with Carbon M2 (CAB) showing the highest values. Stratasys (J5) displayed the highest accuracy in term of precision, while HeyGears A2D4K (HGS), Carbon M2 (CAB), and Stratasys (J5) exhibited the highest accuracy in term of trueness. The inter-molar segment showed the highest deviation. No significant difference was observed in in-tolerance percentage across different print weeks except for week 2 in one printer (Stratasys Origin1). CAB exhibited a higher in-tolerance percentage for the DB than Asiga Max UV (ASG), with the fitting surface having the highest in-tolerance percentage. IPN anterior teeth had a higher intolerance percentage than posterior teeth, with ASG showing a higher value than CAB. No statistically significant difference was found in the in-tolerance percentage of Keysplint Soft Clear between ASG and CAB. Resin printed using ASG demonstrated higher flexural strength, Vickers hardness, and creep, while resin printer using CAB exhibited higher fracture toughness, with no significant difference in surface roughness between the two printers. Lucitone IPN had higher flexural strength and Vickers hardness, surface roughness , and lower creep and fracture toughness than Lucitone DB. CAB Keysplint Soft had higher tensile strength than ASG, with no statistically significant difference in Shore A hardness between the two printers. CONCLUSION: Model dimension deviations were impacted by storage conditions and the specific printer utilized, with high-temperature storage exhibiting the least stability. However, no significant difference was noted between low and room temperature storage conditions. Carbon M2 exhibited the highest level of accuracy. The of 3D-printed denture bases and denture teeth varied across different printers. Conversely, no significant difference in accuracy was observed for a soft occlusal splint between two printers. Materials printed using different printers showed statistically significant different mechanical properties.