The goal of the original research presented in this thesis is to study the strong coupling regime of Quantum Field Theories (QFTs) with different methods, making concrete predictions about the phase structure and the dynamics of these theories, and on their observables. The focus is on (gauge) field theories in three spacetime dimensions, which are an interesting laboratory to understand the properties of strong coupling in setups that are usually simpler than in the more familiar case of gauge theories in four dimensions. Importantly, topological effects play a relevant role in three dimensions, thanks to the presence of the so-called Chern-Simons term.The thesis contains a short introduction to QFTs in 3d, principles and applications of infrared dualities, large N techniques, and holography. Indeed, the web of infrared dualities, the large N expansion, and the holographic correspondence between QFT and gravity are the main tools which we use to investigate the strongly coupled regimes of 3d QFTs.Then, the original material is presented. In a first line of research, we focus on the study of the phase diagram of a 3d gauge theory making use of conjectured infrared dualities, extending such dualities to the case where more than one mass parameter can be dialed. In a second line of research, we study a class of 3d gauge theories by engineering their gravity dual in a string theory setup. We prove the existence of multiple phase transitions between phases characterized by both massless particles and topological sectors. In a third line of research, we use holography as a tool to explore the interplay between the physics of 4d QCD and 3d gauge theories. In particular, we analyze the properties of 3d domain walls, which appear as soliton-like solutions of 4d QCD in specific parametric regimes. Finally, we propose a boundary construction of 3d large N vector models, which appear as critical points of theories obtained by coupling degrees of freedom localized on a 3d boundary to a 4d bulk theory. This construction allows to prove new dualities and uncovers a new computational tool for 3d vector models. / Doctorat en Sciences / info:eu-repo/semantics/nonPublished